|Title||Bayesian-based deconvolution fluorescence microscopy using dynamically updated nonparametric nonstationary expectation estimates|
|Publication Type||Journal Article|
|Year of Publication||2015|
|Authors||Wong, A., X. Wang, and M. Gorbet|
|Journal||Nature Scientific Reports|
Fluorescence microscopy is widely used for the study of biological specimens. Deconvolution can significantly improve the resolution and contrast of images produced using fluorescence microscopy; in particular, Bayesian-based methods have become very popular in deconvolution fluorescence microscopy. An ongoing challenge with Bayesian-based methods is in dealing with the presence of noise in low SNR imaging conditions. In this study, we present a Bayesian-based method for performing deconvolution using dynamically updated nonstationary expectation estimates that can improve the fluorescence microscopy image quality in the presence of noise, without explicit use of spatial regularization.