Subha Kalyaanamoorthy photo
519-888-4567 x35804
ESC 234

Research Interests:

  • Design/discovery of potential therapeutics to target various diseases
  • Understanding the structure and pharmacology of membrane proteins
  • Development of in silico methods/tools for sequence, structure and functional analysis
  • Inferring the structure-function evolution of proteins
  • Protein engineering for biotechnology and pharmaceutical applications

[American Chemical Society] January 23, 2012 "Exploring Inhibitor Release Pathways in Histone Deacetylases Using Random Acceleration Molecular Dynamics Simulations"

[Wiley Online Library] July 27, 2013 "Ligand release mechanisms and channels in histone deacetylases"

[Royal Society of Chemistry] December 19, 2013 "A steered molecular dynamics mediated hit discovery for histone deacetylases"

[Nature Methods] May 8, 2017 "ModelFinder: fast model selection for accurate phylogenetic estimates"

[Royal Society of Chemistry] October 24, 2017 "Reverse engineering: transaminase biocatalyst development using ancestral sequence reconstruction"

Application Areas→Cancer, Cardiovascular, Data Science, Industrial Biotechnology, Neurodegenerative Diseases, Stroke; Technology Areas→Biomaterials, Computational Modeling, Drug Development, Machine Learning/AI, Polymer, Therapeutics; Discipline Areas→Biochemistry, Bioinformatics, Biomedicine, Biophysics, Environmental Biotechnology, Industrial Biotechnology, Pharmacology, Synthetic Biology; Faculty→Science

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