Contact Us:
Centre for Bioengineering and Biotechnology
University of Waterloo, East Campus 4, Room 2001
200 University Avenue West
Waterloo , Ontario, N2L 3G1 Canada
cbb.uwaterloo.ca
519-888-4567 Ext 32732
Chemistry
519-888-4567 x35804
Location:
ESC 234
Research Interests:
- Design/discovery of potential therapeutics to target various diseases
- Understanding the structure and pharmacology of membrane proteins
- Development of in silico methods/tools for sequence, structure and functional analysis
- Inferring the structure-function evolution of proteins
- Protein engineering for biotechnology and pharmaceutical applications
[American Chemical Society] January 23, 2012 "Exploring Inhibitor Release Pathways in Histone Deacetylases Using Random Acceleration Molecular Dynamics Simulations"
[Wiley Online Library] July 27, 2013 "Ligand release mechanisms and channels in histone deacetylases"
[Royal Society of Chemistry] December 19, 2013 "A steered molecular dynamics mediated hit discovery for histone deacetylases"
[Nature Methods] May 8, 2017 "ModelFinder: fast model selection for accurate phylogenetic estimates"
[Royal Society of Chemistry] October 24, 2017 "Reverse engineering: transaminase biocatalyst development using ancestral sequence reconstruction"
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Link to Personal Website or CV:
Group(s):
Application Areas→Cancer, Cardiovascular, Data Science, Industrial Biotechnology, Neurodegenerative Diseases, Stroke; Technology Areas→Biomaterials, Computational Modeling, Drug Development, Machine Learning/AI, Polymer, Therapeutics; Discipline Areas→Biochemistry, Bioinformatics, Biomedicine, Biophysics, Environmental Biotechnology, Industrial Biotechnology, Pharmacology, Synthetic Biology; Faculty→Science