“Exercise Training in Adverse Cardiac Remodeling”

Professor of Experimental Cardiology at Erasmus University, Netherlands
[Poster] [Video]
Abstract:
Cardiac remodeling in response to a myocardial infarction or chronic pressure-overload is an independent risk factor for the development of heart failure. In contrast, cardiac remodeling produced by regular physical exercise is associated with a decreased risk for heart failure. There is evidence that exercise training has a beneficial effect on disease progression and survival in patients with cardiac remodeling and dysfunction, but concern has also been expressed that exercise training may aggravate pathological remodeling and dysfunction. In my talk I will present the results of studies from our laboratory investigating the effects of exercise training on pathological cardiac remodeling and dysfunction in mice, and the mechanisms underlying the divergent effects of physical exercise training in different pathologies.
Biosketch:
Dirk
J.
Duncker
obtained
his
PhD
and
MD
degrees,
respectively,
in
1988
and
1989
at
the
Erasmus
University
Rotterdam.
He
worked
as
a
post-doctorate
research
fellow
at
the
University
of
Minnesota
from
1991-1994,
after
which
he
returned
to
the
Department
of
Cardiology
(Thoraxcenter)
of
the
Erasmus
University
Medical
Center
in
Rotterdam.
In
1995
he
received
a
5
year
Research
Fellowship
Stipend
from
the
Royal
Netherlands
Academy
of
Arts
&
Sciences,
and
in
2000
he
became
Established
Investigator
of
the
Netherlands
Heart
Foundation.
He
was
appointed
Professor
of
Experimental
Cardiology
in
2003.
His
research
interests
include
the
regulation
of
coronary
blood
flow
and
microvascular
tone
in
health
and
disease,
pathophysiology
of
cardiac
hypertrophy
and
heart
failure,
and
the
cardiovascular
effects
of
physical
exercise.
If you are interested in meeting with Dr. Duncker, please email Bernie Duncker.
Pay
parking
available
in
lots
B
or
N
(map)
Event
is
FREE
and
coffee/cookies
will
be
available.