CHEM 400: Multiscale Modeling with Density Functional Theory

This course provides a comprehensive introduction to Density Functional Theory (DFT) and its extensions, equipping students with both theoretical foundations and hands-on computational skills. The curriculum covers essential DFT methodologies, including Kohn-Sham DFT, Classical DFT (cDFT), with applications in materials science, electrochemistry, and biophysics. Students will gain practical experience using state-of-the-art quantum chemistry and solid-state simulation software, such as Gaussian, GAMESS, ORCA, and Quantum ESPRESSO (QE), to model electronic properties, ionic transport, and reaction mechanisms in complex systems.

Topics Covered

  • Fundamentals of Kohn-Sham DFT
    • Principles of electronic structure calculations
    • Self-consistent field (SCF) methods and total energy calculations
  • Exchange-Correlation Functionals
    • Local Density Approximation (LDA)
    • Generalized Gradient Approximation (GGA)
    • Hybrid functionals
  • Computational Aspects in DFT
    • Basis sets and pseudopotentials
    • Periodic boundary conditions and k-point sampling
    • Convergence criteria and accuracy considerations
  • Transition State Theory and Reaction Mechanisms
    • Statistical mechanics
    • Calculating Rates of Chemical Processes Using Transition State Theory
  • Electronic and Diffusion Properties
    • Infrared (IR) and Raman Spectroscopy Calculations
    • Polarizability and Hyperpolarizability Calculations
    • Nuclear Magnetic Resonance (NMR) Predictions
    • ab initio Molecular Dynamics (MD)
  • Classical Density Functional Theory (cDFT)
    • Fundamentals of classical DFT for inhomogeneous fluids
    • Applications in gas and fluid adsorption in porous materials
    • Classical DFT for electrolyte solutions

Course Structure

  • Assignments: Students will engage with reading assignments, including research papers, review articles, and book chapters, with accompanying structured exercises to reinforce theoretical concepts.
  • Computational Labs: Hands-on sessions will provide practical experience using Gaussian, GAMESS, ORCA, and Quantum ESPRESSO, focusing on electronic structure calculations and molecular simulations.
  • Final Project: Instead of a final exam, students will undertake a computational project applying DFT and multiscale modeling to real-world problems in materials science, electrochemistry, or biophysics. Students may choose from suggested topics or propose a project with instructor approval.

Please remember that the Undergraduate Calendar is always the official source for all course descriptions.