Designing cycloadditions to enable total synthesis
Aurélien de la Torre
Assistant Professor
ICMMO, Paris-Saclay University
Wednesday, October 30, 2024
11 a.m.
In-person: C2-361
Abstract: Asymmetric catalysis is a key topic in organic synthesis, as it allows the formation of new bonds while controlling stereogenic centers, which are inherent to natural products and biologically active substances. On the other hand, dual catalysis is an efficient approach to operate multiple chemical operations through a one-pot process. In this presentation, we will discuss our recent developments in asymmetric catalysis1 and dual catalysis2, as well as their application to a concrete total synthesis problem3.
References:
- Huang, G.; Guillot, R.; Kouklovsky, C.; Maryasin, B.; de la Torre, A. Angew. Chem. Int. Ed. 2022, 61, e202208185.
- Chen, B.; Pagès, L.; Dollet, R.; Kouklovsky, C.; Prévost, S.; de la Torre, A. Org. Lett. 2024, 26, 2393-2397.
- Huang, G.; Kouklovsky, C.; de la Torre, A. J. Am. Chem. Soc. 2022, 144, 17803-17807.
Aurélien de la Torre was born and raised in Montpellier, France. There, he obtained his PhD in 2014, working on the total synthesis of isofuranoids under the supervision of Dr. Camille Oger and Dr. Jean-Marie Galano. After a first postdoctoral position in the group of Professor Nuno Maulide (University of Vienna) and a second one in the group of Professor Ilan Marek (Technion – Israel Institute of Technology), he was appointed as Chargé de Recherche CNRS at the Institut de Chimie Moléculaire et des Matériaux d’Orsay (ICMMO, Université Paris-Saclay). He's research interests include total synthesis, asymmetric catalysis, cascade reactions and rearrangements. Recently, he received the 2024 Young Investigator Award from EuChemS Division of Organic Chemistry.