High throughput and on-site analysis using solid-phase microextraction coupled directly to mass spectrometry
Wei Zhou
Postdoctoral Fellow, Department of Chemistry
University of Waterloo
Tuesday, December 10, 2024
9 a.m.
Hybrid: C2-361 and Teams
Abstract: The direct coupling of solid-phase microextraction (SPME) with mass spectrometry (MS) offers rapid analysis with high sensitivity and minimal matrix effects, particularly for complex sample matrices such as biofluids and tissues. This approach has led to the development of high-throughput SPME-MS systems capable of achieving analysis times as short as 30 seconds per sample, utilizing streamlined sample preparation and ambient MS detection techniques. Furthermore, my work on integrating this system with a start-of-art miniature MS, comparable in size to a microwave, opens new avenues for on-site applications, including roadside drug testing, therapeutic drug monitoring in surgical settings, and bed-side testing. The minimal consumption of organic solvents in SPME-MS—requiring as little as a few microliters per sample—aligns with the growing demand for greener and more sustainable analytical methods. This seminar will present the key innovations and applications from my research, highlight challenges addressed during development, and give a future perspective in this field.
References:
- W. Zhou, J. Pawliszyn, Analytica Chimica Acta, 2024, 1291: 342244.
- W. Zhou, J. Pawliszyn, Analytical Chemistry, 2022, 94(45): 15879-15886.
- W. Zhou, E. Nazdrajić, J. Pawliszyn, Analytical Chemistry, 2023, 95(15): 6367-6373.