Department of Chemistry
C2 280
200 University Ave. W
Waterloo, Ontario,
Canada N2L 3G1
Phone: (519) 888-4567 ext 32129
Wednesday, October 19, 2022 — 3:00 PM EDT
The Fall 2022 GWC2 Seminar Series continues Wednesday, October 19th. These seminars will be held in person in the Main Link room at the home University of the presenter, and via Teams for the opposite campus.
Anti-diarrheal Glycoconjugate Vaccines
Professor Mario Monteiro
Department of Chemistry
University of Guelph
Wednesday, October 19, 2022
3:00 p.m.
Main link room at the University of Guelph - Coffee and snacks served.
Online via Microsoft Teams for the University of Waterloo.
Please contact gwc@uoguelph.ca with your Teams ID/email address to attend the seminars online.
All are welcome to attend!
ABSTRACT: Campylobacter jejuni, enterotoxigenic Escherichia coli and Shigellasp. are major causes of bacterial diarrhea worldwide. After fine structural analysis of cell-wall polysaccharide structures, we explored the feasibility of developing a multi-pathogen conjugate vaccine using Escherichia coli proteins as conjugating partners for Campylobacter jejuniand Shigellapolysaccharides. We synthesized glycoconjugate vaccines in which Campylobacter jejunicapsular polysaccharides and Shigella flexnerilipopolysaccharides were conjugated to Escherichia coli adhesins. The vaccines were immunogenic in mice as monovalent, bivalent and trivalent formulations and raised functional antibodies capable of inducing hemagglutination inhibition. The World Health Organization has recently highlighted these conjugate vaccines has a preferred product to combat diarrhea in the developing world. The topics of conversation will focus on our approach to polysaccharide structural and conjugation chemistries taken along the path to human trials.