Guy Guillemette carries out research in the area of biochemistry. His research focuses on the synthesis of nitric oxide by nitric oxide synthase. Nitric oxide is an important endogenous messenger in a variety of physiological and pathophysiological processes.
- Protein structure and function
- nitric oxide synthase
Nitric Oxide (NO) is an important regulator of numerous essential physiological processes like blood pressure, neurotransmission, insulin release, memory storage and the immune response. In addition, NO is involved in a variety of serious pathophysiological processes including septic shock, atherosclerosis, diabetes, as well as myocardial and cerebral ischemia. The biogenesis of NO is catalyzed by Nitric Oxide Synthase (NOS) enzymes. The long-term goal of our research program is to understand the regulation and mechanism of the NOS enzymes.
Guy Guillemette teaches both undergraduate and graduate courses. Course offerings have included topics in biochemistry, biomaterials, and metalloproteins and metalloenzymes.
Recent publications include
- Piazza, M., Guillemette,* J.G., Dieckmann*, T. (2015) Dynamics of nitric oxide synthase-calmodulin interactions at physiological concentrations. Biochemistry 54, 1989-2000. *-corresponding authors
- Piazza, M., Taiakina, V., Guillemette, S.R., Guillemette,* J.G., Dieckmann*, T. (2014) Solution Structure of Calmodulin bound to the target peptide of Endothelial Nitrogen Oxide Synthase phosphorylated at Thr495. Biochemistry 53, 1241-9. *-corresponding authors
- Astashkin, A.,Chen, L., Zhou, X., Li, H., Poulos, T., Liu, Ke, J., Guillemette, J. G., Feng, C. (2014) Pulsed Electron Paramagnetic Resonance Study of Domain Docking in Neuronal Nitric Oxide Synthase: The Calmodulin and Output State Perspective. J. Phys Chem A 118, 6864-72
- Taiakina V, Boone AN, Fux J, Senatore A, Weber-Adrian D, Spafford JD, Guillemette JG. (2013) The calmodulin-binding, short linear motif, NSCaTE is conserved in L-type channel ancestors of vertebrate Cav1.2 and Cav1.3 channels. PLOS ONE 8, e61765, 16 pages
- Labbé G, Krismanich AP, de Groot S, Rasmusson T, Shang M, Brown MD, Dmitrienko GI, Guillemette JG. (2012) Development of metal-chelating inhibitors for the Class II fructose 1,6-bisphosphate (FBP) aldolase. J. Inorg. Biochem 112, 49-58.
Patent Application – “Spatio-Temporal Activation, Site Selection, and Monitoring of Treatment Agent and Activity Thereof Using EMR”, Jervis E.J., Guillemette J.G., Perdicakis B., Montgomery H.J., Lajoie G.A. Fishlock D., US and European Patent Applications Filed Oct 12, 2005.
Awards and Distinctions
FRSQ Chercheur-Boursier ($43,000/yr towards salary) Investigation of the function of the pyruvate dehydrogenase enzyme. Declined after June 30, 1995, 1993-1997
Scholarship from the Huntington’s Society of Canada, 1986
OGS scholarship, 1985
Scholarship from the Huntington’s Society of Canada, 1984
University of Waterloo Affiliations
- Member of the Institute of Biochemistry & Molecular Biology
Professional Associations and Service
- Editorial Board member, Biochemical Research Letters, 2009-present
- Journal of Biomedicine and Biotechnology, 2008-present
- (GWC)2 Director, 2012-2015
- Science Faculty Council, 2012-2015
- Chemistry Safety committee, 2015
- Graduate Officer, 2009-2012
- IBMB Director, 2009-2012
- Graduate advisor committee, 2009-2012
- (GWC)2 Coordinating Committee, 2005-2012
- Undergraduate Relations Committee, 2003-2012
1988 PhD, Biochemistry, University of Toronto
1981 BSc, Biochemistry, University of Toronto