200 University Ave. W
Waterloo, Ontario, Canada N2L 3G1
Phone: (519) 888-4567 ext 32129
Fax: (519) 746-0435
Room: ESC 246
Chair's office extension: 34763
Research office extension: 35817
Website: John Honek
Our interest is to understand the fundamental interactions of small molecules (such as substrates and drugs) with enzymes as well as the mechanisms by which enzymes catalyze reactions. Research in this area includes mechanistic enzymology, recombinant DNA and biophysical methods as well as organic synthesis, medicinal chemistry and molecular modeling. An additional focus is in the area of bionanotechnology and the application of biological chemistry to the synthesis of new nanomaterials and nanostructures.
Petrie, A. A., van der Ven, A. M., and Honek, J. F. 2013, Nanomaterial-based Biosensors in Biosensors and Their Applications in Healthcare: Hot Topics, eBook, Future Science Ltd., U.K.
J. F. Honek, 2013, Aeruginolysin in Handbook of Proteolytic Enzymes 3rd Edition. Rawlings, N. D. and Salvesen, G. Eds., Elsevier Limited, 867-872.
M. Palmer, A. Chan, T. Dieckmann and J. Honek, 2012, Biochemical Pharmacology, Wiley-VCH.
K. Y. Mullings, N. Sukdeo, U. Suttisansanee, Y. Ran, and J. F. Honek, 2012, Ni2+-Activated Glyoxalase I from Escherichia coli: Substrate Specificity, Kinetic Isotope Effects and Evolution Within the βαβββ Superfamily. Journal of Inorganic Biochemistry, 108, 133-140.
U. Suttisansanee, K. Lau, S. Lagishetty, K. N. Rao, S. Swaminathan, J. M. Sauder, S. K. Burley and J. F. Honek, 2011, Structural Variation in Bacterial Glyoxalase I Enzymes: Investigation of the Metalloenzyme Glyoxalase I from Clostridium acetobutylicum. Journal of Biological Chemistry, 286, 38367-38374.