200 University Ave. W
Waterloo, Ontario, Canada N2L 3G1
Phone: (519) 888-4567 ext 32129
Fax: (519) 746-0435
Room: ESC 246
Chair's office extension: 34763
Research office extension: 35817
Website: John Honek
Our interest is to understand the fundamental interactions of small molecules (such as substrates and drugs) with enzymes as well as the mechanisms by which enzymes catalyze reactions. Research in this area includes mechanistic enzymology, recombinant DNA and biophysical methods as well as organic synthesis, medicinal chemistry and molecular modeling. An additional focus is in the area of bionanotechnology and the application of biological chemistry to the synthesis of new nanomaterials and nanostructures.
C. L. Myers, E. G. Kuiper, P. C. Grant, J. Hernandez, G. L. Conn, and J. F. Honek, 2015, Functional Roles in S-Adenosyl-L-Methionine Binding and Catalysis for Active Site Residues of the Thiostrepton Resistance Methyltransferase. FEBS Letters, 589, 3263-3270.
J. F. Honek, 2015, Biological Chemistry of the Carbon-Sulfur Bond. Canadian Journal of Chemistry, 93, 1051-1060.
U. Suttisansanee, Y. Ran, K. Y. Mullings, N. Sukdeo, and J. F. Honek, 2015, Modulating Glyoxalase I Metal Selectivity by Deletional Mutagenesis: Underlying Structural Factors Contributing to Nickel Activation Profiles. Metallomics, 7, 605-612.
R. Bythell-Douglas, U. Suttisansanee, G. R. Flematti, M. Challenor, M. Lee, S. Panjikar, J. F. Honek and C. S. Bond, 2015, The Crystal Structure of a Homodimeric Pseudomonas Glyoxalase I Enzyme Reveals Asymmetric Metallation Commensurate with Half-of-Sites Activity. Chemistry - A European Journal, 21, 541-544.
C. L. Myers, J. Harris, J. C. K. Yeung, and J. F. Honek, 2014, Molecular Interactions Between Thiostrepton and the TipAS Protein from Streptomyces lividans. ChemBioChem, 15, 681-687.