Scott Taylor's research is highly interdisciplinary ranging from synthetic organic chemistry to medicinal chemistry and enzymology, to the development of new bionanomaterials. He develops new synthetic methodology and applies it to the synthesis of novel biomolecules and materials such as modified steroids, carbohydrates, amino acids, peptides, nucleosides, nucleotides and starch nanoparticles. Novel biomolecules are evaluated as antibiotics and enzyme inhibitors, while the biomaterials are evaluated for their potential industrial applications.
- Biological and medicinal chemistry
- Synthetic methodology
Scott Taylor’s research program is currently focussed on four key areas: (1) the synthesis and study of cyclic lipodepsipeptide antibiotics; (2) the development of novel phosphorylation chemistry and its application to the synthesis of inhibitors of cytidine triphosphate synthase, an anti-cancer and antiviral target; (3) the development of inhibitors of steroid sulfatase, a breast cancer target and, (4) the modification of starch nanoparticles which are evaluated for their ability to extract oil from oil sands and as novel wound dressings.
A wide variety of techniques are employed such as nuclear magnetic resonance, fluorimetry, high-performance liquid chromatography, protein purification, spectrophotometry, mass spectrometry, differential scanning calorimetry and dynamic light scattering.
- Medicinal Chemistry
- Organic Chemistry for Chemical Engineers
- Introduction to Bioorganic and Medicinal Chemistry
- Introductory Organic Chemistry
Recent publications include
- Mohamady, S.; Taylor, S.D. Synthesis of nucleoside triphosphates from 2'-3'-protected nucleosides using trimetaphosphate. Org. Lett. 2016, 18, 580-583.
- Taylor, R.; Butt, K.; Scott. B.; Zhang, T.; Muraih, J. K.; Mintzer, E.; Duhamekl, J.; Taylor, S. D.; Palmer, M. Two succesive Ca+2-dependent transitions medite membrane binding and oligomerization of daptomycin and the related antibiotic A54145. Biochim. Biophys. Acta – Biomembranes, 2016, 1858, 1999-2005.
- Lohani, C. R.; Taylor, S. D. A fresh look at the Staudinger reaction on azido esters: Formation of 2H-1,2,3-triazol-4-ols from a-azido ester using trialkylphosphines. Org Lett. 2016, 18, 4412-4415.
- Lohani, C.R.; Taylor, R.; Palmer, M.; Taylor, S.D. Solid-phase total synthesis of daptomycin and analogs. Org Lett. 2015, 17, 748-751.
- Mostafa, Y.A.; Kralt, B.; Rao, P.P.; Taylor, S.D. A-ring substituted 17β-arylsulfonamides of 17β-aminoestra-1,3,5(10)-trien-3-ol as highly potent reversible inhibitors of steroid sulfatase. Bioorg Med Chem. 2015, 23, 5681-5692.
Awards and Distinctions
- Outstanding Performance Award, 2012 & 2017
- Premiere’s Research Excellence Award, 2000
- International Union of Pure and Applied Chemists (IUPAC) Travel Award, 1997
- Natural Sciences and Engineering Research Council of Canada (NSERC) Post-Doctoral Fellowship, Dept. of Chemistry, The Pennsylvania State University, 1992-94
- Ontario Graduate Scholarship, Dept. of Chemistry, University of Toronto, 1990-91
- Natural Sciences and Engineering Research Council of Canada (NSERC) Post-Graduate Scholarship B, Dept. of Chemistry, University of Toronto, 1988-90
- Bio-Mega Boehringer Ingelheim Inc. Award for excellence in graduate research, Dept. of Chemistry, University of Toronto, 1990
- Ontario Graduate Scholarship, Dept. of Chemistry, University of Toronto, 1987-88
- George F. Wright Seminar Award for outstanding graduate student presentation, Dept. of Chemistry, University of Toronto, 1988
- Faculty Scholar, McGill University, 1984-85
University of Waterloo Affiliations
- Member of the Institute of Biochemistry & Molecular Biology
- Member of the Waterloo Institute for Nanotechnology
Professional Associations and Service
- Chair, Mass spec users committee, 2014-present
- Awards committee, 2013-present
- NMR users committee, 2000-present
February 4, 2015: Chemists develop new method to improve the discovery of antibiotics
1991 Ph.D. Chemistry, University of Toronto, Toronto, ON
1986 B.Sc. Biochemistry, McGill University, Montreal, QC