Scott Taylor's research is highly interdisciplinary ranging from synthetic organic chemistry to medicinal chemistry and enzymology, to the development of new bionanomaterials. He develops new synthetic methodology and applies it to the synthesis of novel biomolecules and materials such as modified steroids, carbohydrates, amino acids, peptides, nucleosides, nucleotides and starch nanoparticles. Novel biomolecules are evaluated as antibiotics and enzyme inhibitors, while the biomaterials are evaluated for their potential industrial applications.
- Biological and medicinal chemistry
- Synthetic methodology
Scott Taylor’s research program is currently focussed on four key areas: (1) the synthesis and study of cyclic lipodepsipeptide antibiotics; (2) the development of novel phosphorylation chemistry and its application to the synthesis of inhibitors of cytidine triphosphate synthase, an anti-cancer and antiviral target; (3) the development of inhibitors of steroid sulfatase, a breast cancer target and, (4) the modification of starch nanoparticles which are evaluated for their ability to extract oil from oil sands and as novel wound dressings.
A wide variety of techniques are employed such as nuclear magnetic resonance, fluorimetry, high-performance liquid chromatography, protein purification, spectrophotometry, mass spectrometry, differential scanning calorimetry and dynamic light scattering.
- Medicinal Chemistry
- Organic Chemistry for Chemical Engineers
- Introduction to Bioorganic and Medicinal Chemistry
- Introductory Organic Chemistry
Recent publications include
Moreira, R.; Barnawi, G.; Beriashvili, D.; Palmer, M.; Taylor, S. D.* The effect of replacing the ester bond with an amide bond and of overall stereochemistry on the activity of daptomycin. Bioorg Med Chem. 2018, doi: 10.1016/j.bmc.2018.12.004
Mohamady, S.; Taylor, S. D.* Synthesis of nucleoside‐5′‐O‐tetraphosphates from activated trimetaphosphate and nucleoside‐5′‐O‐monophosphates, Curr. Protoc. Nucleic Acid Chem. 2018, doi: 10.1002/cpnc
Moreira, R.; Taylor, S. D.* Asymmetric synthesis of Fmoc-protected β-hydroxy and β-methoxy amino acids via a Sharpless aminohydroxylation reaction using FmocNHCl. Org. Lett. 2018, 20, 7717–7720.
Mohammady, S.;* Kralt, B,; Samwel, S. K.; Taylor, S. D. Efficient one-Pot, two-component modular synthesis of 3,5-disubstituted pyrazoles. ACS Omega, 2018, 3, pp 15566–15574.
Beriashvili, D.; Taylor, R.; Kralt, B.; Abu Mazen, N.; Taylor, S. D.; Palmer, M.* Mechanistic studies on the effect of membrane lipid acyl chain composition on daptomycin pore formation. Chem Phys Lipids. 2018, 216, 73–79.
Barnawi, G.; Noden, M.; Taylor, R.; Lohani, C.; Beriashvili, D.; Palmer, M*.; Taylor, S. D.* An entirely Fmoc solid phase approach to the synthesis of daptomycin analogs. Biopolymers: Peptide Sci. 2018, doi: 10.1002/bip.23094.
Awards and Distinctions
- Outstanding Performance Award, 2012 & 2017
- Premiere’s Research Excellence Award, 2000
- International Union of Pure and Applied Chemists (IUPAC) Travel Award, 1997
- Natural Sciences and Engineering Research Council of Canada (NSERC) Post-Doctoral Fellowship, Dept. of Chemistry, The Pennsylvania State University, 1992-94
- Ontario Graduate Scholarship, Dept. of Chemistry, University of Toronto, 1990-91
- Natural Sciences and Engineering Research Council of Canada (NSERC) Post-Graduate Scholarship B, Dept. of Chemistry, University of Toronto, 1988-90
- Bio-Mega Boehringer Ingelheim Inc. Award for excellence in graduate research, Dept. of Chemistry, University of Toronto, 1990
- Ontario Graduate Scholarship, Dept. of Chemistry, University of Toronto, 1987-88
- George F. Wright Seminar Award for outstanding graduate student presentation, Dept. of Chemistry, University of Toronto, 1988
- Faculty Scholar, McGill University, 1984-85
University of Waterloo Affiliations
- Member of the Institute of Biochemistry & Molecular Biology
- Member of the Waterloo Institute for Nanotechnology
Professional Associations and Service
- Chair, Mass spec users committee, 2014-present
- Awards committee, 2013-present
- NMR users committee, 2000-present
1991 Ph.D. Chemistry, University of Toronto, Toronto, ON
1986 B.Sc. Biochemistry, McGill University, Montreal, QC