Scott Taylor

• Biological and medicinal chemistry
• Synthetic methodology
• Enzymology
• Bionanomaterials

Scott Taylor’s research program is currently focussed on four key areas: (1) the synthesis and study of cyclic lipodepsipeptide antibiotics; (2) the development of novel phosphorylation chemistry and its application to the synthesis of inhibitors of cytidine triphosphate synthase, an anti-cancer and antiviral target; (3) the development of inhibitors of steroid sulfatase, a breast cancer target and, (4) the modification of starch nanoparticles which are evaluated for their ability to extract oil from oil sands and as novel wound dressings. 

A wide variety of techniques are employed such as nuclear magnetic resonance, fluorimetry, high-performance liquid chromatography, protein purification, spectrophotometry, mass spectrometry, differential scanning calorimetry and dynamic light scattering.

• Medicinal Chemistry
• Organic Chemistry for Chemical Engineers
• Introduction to Bioorganic and Medicinal Chemistry
• Introductory Organic Chemistry

Recent publications include

• Kralt, B.; Moreira, R.; Palmer, M.; Taylor, S. D.* Total Synthesis of Analogs of A54145D and A54145A1 for Structure-Activity Relationship Studies. 2020, in press.

• Soley, J.; Taylor, S. D.* A Mild, Rapid, Chemo- and Regioselective Procedure for the Introduction of the 9-Phenyl-9-fluorenyl Protecting Group into Amines, Acids, Alcohols, Sulfonamides and Amides. J. Org. Chem. 2020, in press

• Mohamady, S.; Ismaila, M. I.; Mogheith, S. M.; Attiac, Y. M.; Taylor, S. D. Discovery of 5-Aryl-3-Thiophen-2-yl-1H-Pyrazoles as a New Class of HSP90 Inhibitors in Hepatocellular Carcinoma. Bioorg.Chem., 2020, 103433.

• Moreira, R.; Diamandas, M.; Taylor, S. D.* Synthesis of Fmoc-protected amino alcohols via the Sharpless asymmetric aminohydroxylation reaction using FmocNHCl as the nitrogen source. J. Org. Chem. 2019, 84, 15476-15485.

• Kralt, B.; Moreira, R.; Palmer, M.; Taylor, S. D.* Total synthesis of A5145 factor D. J. Org. Chem. 2019, 84, 12021-12030.

• Noden, M.; Moreira, R.; Huang, E.; Yousef, A.; Palmer, M.; Taylor, S. D.* Total Synthesis of Paenibacterin and its Analogs. J. Org. Chem., 2019, 8, 5339-5347.

• Zheng, B.; Karski, M.; Taylor, S. D.* Thermoresponsive hydroxybutylated starch nanoparticles.  Carbohydr. Polymers, 2019, 206, 145-151.

• Moreira, R.; Barnawi, G.; Beriashvili, D.; Palmer, M.; Taylor, S. D.* The effect of replacing the ester bond with an amide bond and of overall stereochemistry on the activity of daptomycin.  Bioorg. Med. Chem. 2019, 27, 240-246.

• Outstanding Performance Award, 2012 & 2017
• Premiere’s Research Excellence Award, 2000      
• International Union of Pure and Applied Chemists (IUPAC) Travel Award, 1997     
• Natural Sciences and Engineering Research Council of Canada (NSERC) Post-Doctoral Fellowship, Dept. of Chemistry, The Pennsylvania State University, 1992-94      
• Ontario Graduate Scholarship, Dept. of Chemistry, University of Toronto, 1990-91  
• Natural Sciences and Engineering Research Council of Canada (NSERC) Post-Graduate Scholarship B, Dept. of Chemistry, University of Toronto, 1988-90    
• Bio-Mega Boehringer Ingelheim Inc. Award for excellence in graduate research, Dept. of Chemistry, University of Toronto, 1990   
• Ontario Graduate Scholarship, Dept. of Chemistry, University of Toronto, 1987-88  
• George F. Wright Seminar Award for outstanding graduate student presentation, Dept. of Chemistry, University of Toronto, 1988      
• Faculty Scholar, McGill University, 1984-85 

• Member of the Institute of Biochemistry & Molecular Biology
• Member of the Waterloo Institute for Nanotechnology

• Chair, Mass spec users committee, 2014-present
• Awards committee, 2013-present
• NMR users committee, 2000-present

• April 17, 2015: Waterloo scientists win Seed Fund for antibiotic and lung disease research

• February 4, 2015:  Chemists develop new method to improve the discovery of antibiotics

1991 Ph.D. Chemistry, University of Toronto, Toronto, ON

1986 B.Sc. Biochemistry, McGill University, Montreal, QC