Scott Taylor

• Biological and medicinal chemistry
• Synthetic methodology
• Enzymology
• Bionanomaterials

Scott Taylor’s research program is currently focussed on four key areas: (1) the synthesis and study of cyclic lipodepsipeptide antibiotics; (2) the development of novel phosphorylation chemistry and its application to the synthesis of inhibitors of cytidine triphosphate synthase, an anti-cancer and antiviral target; (3) the development of inhibitors of steroid sulfatase, a breast cancer target and, (4) the modification of starch nanoparticles which are evaluated for their ability to extract oil from oil sands and as novel wound dressings. 

A wide variety of techniques are employed such as nuclear magnetic resonance, fluorimetry, high-performance liquid chromatography, protein purification, spectrophotometry, mass spectrometry, differential scanning calorimetry and dynamic light scattering.

• Medicinal Chemistry
• Organic Chemistry for Chemical Engineers
• Introduction to Bioorganic and Medicinal Chemistry
• Introductory Organic Chemistry

Recent publications include

• Mohamady, S.; Taylor, S.D. Synthesis of nucleoside triphosphates from 2'-3'-protected nucleosides using trimetaphosphate.  Org. Lett. 2016, 18, 580-583.
• Taylor, R.; Butt, K.; Scott. B.; Zhang, T.; Muraih, J. K.; Mintzer, E.; Duhamekl, J.; Taylor, S. D.; Palmer, M. Two succesive Ca⁺²-dependent transitions medite membrane binding and oligomerization of daptomycin and the related antibiotic A54145. Biochim. Biophys. Acta – Biomembranes, 2016, 1858, 1999-2005.
• Lohani, C. R.; Taylor, S. D. A fresh look at the Staudinger reaction on azido esters: Formation of 2H-1,2,3-triazol-4-ols from a-azido ester using trialkylphosphines. Org Lett. 2016, 18, 4412-4415.
• Lohani, C.R.; Taylor, R.; Palmer, M.; Taylor, S.D. Solid-phase total synthesis of daptomycin and analogs. Org Lett. 2015, 17, 748-751.
• Mostafa, Y.A.; Kralt, B.; Rao, P.P.; Taylor, S.D. A-ring substituted 17β-arylsulfonamides of 17β-aminoestra-1,3,5(10)-trien-3-ol as highly potent reversible inhibitors of steroid sulfatase. Bioorg Med Chem. 2015, 23, 5681-5692.

• Outstanding Performance Award, 2012 & 2017
• Premiere’s Research Excellence Award, 2000      
• International Union of Pure and Applied Chemists (IUPAC) Travel Award, 1997     
• Natural Sciences and Engineering Research Council of Canada (NSERC) Post-Doctoral Fellowship, Dept. of Chemistry, The Pennsylvania State University, 1992-94      
• Ontario Graduate Scholarship, Dept. of Chemistry, University of Toronto, 1990-91  
• Natural Sciences and Engineering Research Council of Canada (NSERC) Post-Graduate Scholarship B, Dept. of Chemistry, University of Toronto, 1988-90    
• Bio-Mega Boehringer Ingelheim Inc. Award for excellence in graduate research, Dept. of Chemistry, University of Toronto, 1990   
• Ontario Graduate Scholarship, Dept. of Chemistry, University of Toronto, 1987-88  
• George F. Wright Seminar Award for outstanding graduate student presentation, Dept. of Chemistry, University of Toronto, 1988      
• Faculty Scholar, McGill University, 1984-85 

• Member of the Institute of Biochemistry & Molecular Biology
• Member of the Waterloo Institute for Nanotechnology

• Chair, Mass spec users committee, 2014-present
• Awards committee, 2013-present
• NMR users committee, 2000-present

• February 4, 2015:  Chemists develop new method to improve the discovery of antibiotics

1991 Ph.D. Chemistry, University of Toronto, Toronto, ON

1986 B.Sc. Biochemistry, McGill University, Montreal, QC