Thorsten Dieckmann's research interests include the biophysics of RNA, structure and function of RNA and proteins, high resolution NMR spectroscopy, catalysis, drug design, viral infections, RNA world and the origin of life.
Thorsten is the Director of the Insititute of Biochemistry & Molecular Biology.
- Nuclear Magnetic Resonance (NMR)-spectroscopy
- Ribonucleic acid (RNA) and protein structure
- RNA-protein interactions
- RNA catalysis
- Viral infections
- Cellular defense mechanisms
Thorsten Dieckmann's research focuses on two areas of RNA related research: Small RNAs with interesting ligand binding or catalytic properties and the structure and function of RNA-protein complexes.
The structure determination of RNA and RNA-protein complexes by NMR requires the development and application of heteronuclear, multi-dimensional NMR techniques in combination with complete or specific 13C, 15N, and 2H labeling of the molecules under investigation. In addition in vitro selection can be applied to find RNAs with high affinities for target proteins or modules of these proteins. The study of ion-binding to RNA and the investigation of the molecular dynamics of free RNAs and their complexes will add to a more complete picture of the structure and function of RNA and RNA-protein interactions on a molecular level.
Thorsten Dieckmann teaches both undergraduate and graduate courses. Course offerings have included topics in biochemistry.
Recent publications include
- Pimlott, Douglas, Guy Guillemette, and Thorsten Dieckmann. "Structural Investigation of Melatonin Metabolites as Calmodulin Antagonists and potential Nitric Oxide Synthase Inhibitors." The FASEB Journal 33.1_supplement (2019): 784-12.
- Anwar, A., Psutka, J., Walker, S.W.C., Dieckmann, T., Janizewski, J.S., Larry Campbell, J., Scott Hopkins, W. Separating and probing tautomers of protonated nucleobases using differential mobility spectrometry. International Journal of Mass Spectrometry (2018) 429, pp. 174-181.
- Psutka, J.M., Dion-Fortier, A., Dieckmann, T., Campbell, J.L., Segura, P.A., Hopkins, W.S. Identifying Fenton-Reacted Trimethoprim Transformation Products Using Differential Mobility Spectrometry (2018) Analytical Chemistry, 90 (8), pp. 5352-5357.
- Piazza, M., Taiakina, V., Dieckmann, T., Guillemette, J.G. Structural Consequences of Calmodulin EF Hand Mutations (2017) Biochemistry, 56 (7), pp. 944-956.
- Chemin, J., Taiakina, V., Monteil, A., Piazza, M., Guan, W., Stephens, R.F., Kitmitto, A., Pang, Z.P., Dolphin,A.C., Perez-Reyes, E., Dieckmann, T., Guillemette, J.G., Spafford, J.D. Calmodulin regulates Cav3 T-type channels 3 at their gating brake (2017) Journal of Biological Chemistry, 292 (49), pp. 20010-20031.
- Piazza, M., Dieckmann, T., & Guillemette, J. G. (2016). Structural studies of a complex between endothelial nitric oxide synthase and calmodulin at physiological calcium concentration. Biochemistry, 55:5962-5971.
Please see Thorsten Dieckmann's laboratory website for a current list of his peer-reviewed articles.
Awards and Distinctions
- Award of the degree “Dr. rer. nat” with honors (mit Auszeichnung) by the Technical University of Braunschweig, Germany, 1993
- Long-term postdoctoral fellowship of the Human Frontier Science Program Organization, Strasbourg, France, 1994 to 1996.
University of Waterloo Affiliations
- Director of the Institute of Biochemistry and Molecular Biology
Professional Associations and Service
Advisor, Biochemistry Program, 2014-present
Guelph-Waterloo Centre for Graduate Work in Chemistry and Biochemistry (GWC2) steering committee, 2011-present
Executive Committee, 2010-present
Member of the Board, Faculty of Science Foundation, 2010-2014
Executive Director, Faculty of Science Foundation, 2009-2010
1993 Dr. rer. nat., Technical University of Braunschweig, Germany
1991 Dipl. Chem., Technical University of Braunschweig, Germany