This course explores the principles and emerging frontiers of aqueous self-assembly within the broader context of supramolecular chemistry. It begins with foundational concepts, including non-covalent interactions, molecular recognition, and the thermodynamics driving self-assembly. Students will examine current methodologies used to characterize supramolecular assemblies and recent advances in living self-assembly systems. Special attention will be given to how aqueous environments influence molecular behavior, hierarchical organization, and their associated functions. Emphasis will be placed on the unique role of water, which not only acts as a solvent but also as an active participant in modulating assembly pathways and structural outcomes. Through critical literature review, discussions, and written assignments, students will develop self-directed learning skills and engage with cutting-edge research. The course culminates with an analysis of ongoing challenges in the field and strategies to advance aqueous self-assembly for applications in materials science, biology, and nanotechnology.
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