Organic Chemistry 3
- For honours students only.
This course will familiarize students with some of the modern synthetic methods for the formation of carbon-carbon bonds in organic compounds. An array of anionic, pericyclic, and organometallic methods will be introduced, namely condensations and α-substitutions of carbonyl compounds, conjugate addition to α,ß-unsaturated carbonyl compounds, cycloaddition reactions, and organometallic-promoted reactions, with a particular attention to Pd-catalyzed cross-coupling reactions (Heck, Stille, and Suzuki). The factors dictating the stereochemical and regiochemical course of some of these carbon-carbon bond-forming processes will be presented and discussed. Furthermore, the outcome of these organic transformations will be rationalized by detailed analysis of the reactions mechanisms. For cycloadditions, the reactivity of the systems, as well as the relative reaction rates, regiochemistry and stereochemistry will be predicted using the frontier molecular orbitals involved in the bond forming and bond breaking events.
Please remember that the Undergraduate Calendar is always the official source for all course descriptions.