Spectroscopy in Organic Chemistry
This course deals with the theory and applications of selected spectroscopic methods in organic chemistry. Practical aspects of obtaining meaningful spectra will be covered and considerable emphasis will be placed on applications to structural elucidation. Treatment of theory will be relatively non-mathematical, and will be presented as exercises in structural characterization of unknowns. The course will start with a survey of mass spectrometry, including the theory, the instrumentation, the ionization methods, and how it can be applied to structural determination. This will be followed by a study of infrared spectroscopy, and its application in structural elucidation. A large portion of this course will focus on Nuclear Magnetic Resonance (NMR) spectroscopy, beginning with a discussion of NMR theory and instrumentation. This will be followed by a discussion of 1H NMR, including chemical shift, spin-spin coupling, equivalence of nuclei, and analysis of non-first order spectra. A discussion of 13C NMR spectroscopy will follow, including chemical shift, coupled/decoupled spectra, and J-MOD spectra (APT and DEPT). Lastly, 2D NMR techniques will be discussed, including H/H COSY, H/C COSY (HETCOR, HSQC, HMQC), as well as long-range H/C spectra (HMBC).
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