Tuesday, December 14, 2021
His award-winning talk described the efforts of the Taylor Lab to determine the chiral target of daptomycin (dap) – a clinical antibiotic used to treat drug-resistant infections. Through studying the interaction of dap with phosphatidylglycerol (PG) while manipulating the stereochemistry of both molecules using synthetic chemistry, the Taylor Lab showed that dap-PG interactions are strongly dependent on the stereochemistry of each component. Based on this work, they concluded that the chiral target of dap is a stereoisomer of PG.
Congratulations, Ryan!