David Sychantha

David Sychantha
Assistant Professor
Location: ESC 233
Phone: 519-888-4696‬ x43076


Dr. David Sychantha earned his Ph.D. from the University of Guelph under the supervision of Dr. Anthony Clarke. His thesis research focused on investigating bacterial polysaccharide O-acetylation in Gram-positive bacteria. He then underwent postdoctoral training in Dr. Gerry Wright's laboratory at McMaster University, during which he characterized the modes of action of several antibiotics, antibiotic adjuvants, and anti-virulence agents.

The Sychantha Lab employs structural biology, enzymology, and chemical biology approaches to study how pathogenic bacteria maintain and modify their cell surfaces to resist antibiotics and evade the human immune system. Specifically, the lab is interested in the biochemical pathways bacteria use to regulate enzymes involved in remodelling the cell wall and controlling cell shape/structure. The long-term goal of the lab is to define the mechanisms of cell wall homeostasis to inform chemotherapeutic strategies to combat infections caused by antibiotic-resistant bacteria.

Research Interests

  • Microbiology & Immunology
  • Antibiotics & Resistance
  • Structural enzymology
  • Glycobiology


  • 2023 CIHR Fellow, McMaster University
  • 2018 Ph.D., Molecular & Cellular Biology, University of Guelph
  • 2013 M.Sc., Molecular & Cellular Biology, University of Guelph
  • 2011 B.Sc., Microbiology, University of Guelph


  • 2020 - 2023 CIHR Fellowship Award
  • 2018 - 2019 Michael G. DeGroote Fellowship Award

Graduate studies