Jung-Ho Yu

Jung-Ho Yu
Assistant Professor
Location: QNC 4614


Professor Jung-Ho Yu's research group at the University of Waterloo is innovating nanotechnology-based bioanalytical platforms that enable multiplexed, spatial, and longitudinal monitoring of molecular signals within live biological environments.

During his PhD at Seoul National University and postdoc at Stanford University, he pioneered atomic-scale digital doping chemistry of semiconductor nanoclusters and artificial two-dimensional materials. His groundbreaking work in atomic-scale doping led to the development of biocompatible nanocrystal phosphors and their first demonstration of in vivo three-photon microscopy.

Prior to joining the University of Waterloo, he worked as a research scientist at the Molecular Imaging Program at Stanford (MIPS) and The Center for Cancer Nanotechnology Excellence for Translational Diagnostics (CCNE-TD) at Stanford School of Medicine. During this period, he innovated multiplexed surface-enhanced Raman spectroscopy (SERS) to visualize live models of heterogeneous tumors and drove its translation by designing an in vivo excretable supramolecular nanocluster imaging agent.

Research Interests

  • Chemical Spectroscopy
  • Molecular Imaging
  • Nanotechnology
  • Bioanalytical Chemistry


  • 2010, PhD, Chemical and Biological Engineering, Seoul National University, South Korea
  • 2003, BS, Chemical Engineering, Seoul National University, South Korea

Professional Associations

  • American Chemical Society
  • Materials Research Society
  • World Molecular Imaging Society

Affiliations and Volunteer Work

  • Waterloo Institute for Nanotechnology


  • CHEM 221 - Multi-Component Analysis
    • Taught in 2024

* Only courses taught in the past 5 years are displayed.

Selected/Recent Publications

  • J.H. Yu*, M.-S. J., E.O. Cruz, I.S. Alam, S.K. Tumbale, A. Zlitni, S.Y. Lee, H.-Y. Chuang, Y.-I. Park, K. Ferrara, S.-H. Kwon, S.S. Gambhir, and J. Rao*, “Highly Excretable Gold Supraclusters for Translatable In Vivo Raman Imaging of Tumors.” ACS Nano 2023, 17, 2554-2567. (*Co-corresponding author)
  • J.H. Yu*, I. Steinberg, R.M. Davis, A.V. Malkovskiy, A. Zlitni, R.K. Radzyminski, K.O. Jung, D.T. Chung, L.D. Curet, A.L. D'Souza, E. Chang, J. Rosenberg, J. Campbell, H. Frostig, S.-m. Park, G. Pratx, C. Levin, and S.S. Gambhir*, “Noninvasive and Highly Multiplexed Five-Color Tumor Imaging of Near-Infrared Resonant Surface-Enhanced Raman Nanoparticles In Vivo.” ACS Nano 2021, 15, 19956-19969. (*Co-corresponding author)
  • J. E. Olson, J.H. Yu*, R. L. Thimes, J.P. Camden* “Vibrational Two-Photon Microscopy for Tissue Imaging: Short-Wave Infrared Surface-Enhanced Resonant Hyper-Raman Scattering.” J. Biophotonics 2021, e202100158. (*Co-corresponding author)
  • S. Park, A. Aalipour, O. Vermesh, J.H. Yu, and S.S. Gambhir, “Toward Clinically Translatable in vivo Nanodiagnostics (Invited Review).” Nat. Rev. Mater. 2017, 2, 17014.
  • J.H. Yu*, S.-H. Kwon*, Z. Petrášek, O.K. Park, S.W. Jun, K. Shin, M. Choi, Y.I. Park, K. Park, H.B. Na, N. Lee, D.W. Lee, J.H. Kim, P. Schwille, and T. Hyeon, “High-resolution three-photon biomedical imaging using doped ZnS nanocrystals.” Nat. Mater. 2013, 12, 359-366. (see also “Bioimaging: Illuminating the deep.” Nat. Mater. 2013, 12, 285-287. (News and Views))
  • J.H. Yu*, X. Liu*, K. E. Kweon, J. Joo, J. Park, K.-T. Ko, D.W. Lee, S. Shen, K. Tivakornsasithorn, J.S. Son, J.-H. Park, Y.-W. Kim, G. S. Hwang, M. Dobrowolska, J.K. Furdyna, and T. Hyeon, “Giant Zeeman Splitting in Nucleation-Controlled Doped CdSe:Mn2+ Quantum Nanoribbons.” Nat. Mater. 2010, 9, 47-53.

Graduate studies