University of Waterloo
200 University Ave W, Waterloo, ON
N2L 3G1
Phone: (519) 888-4567
Staff and Faculty Directory
Contact the Department of Electrical and Computer Engineering
Tianchi Ma
Christopher Backhouse
An Automated Hand-held RFLP-CE Diagnosis Device for point-of-care Applications
Micro-Total-Analysis-System (uTAS) for genetic diagnosis has a great potential to revolutionize the future of health care. However the lack of uTAS, which is fully integrated, mass-producible and application oriented, has delayed uTAS development in real life point-of-care applications.
In this presentation, I will discuss our automatic system developed for a polymer-based diagnosis system capable of sample preparation (SP) and the capillary electrophoresis (CE) based restriction fragment length polymorphism (RFLP). Both processes, SP and CE, are integrated through a novel valve/pumping module, and it is fully capable of hand-free operation. This current system has demonstrated the mutation detection related to hereditary hemochromatosis (HFE). In addition, all of these modules were intended to be developed in a manner that could be implemented in a PMMA chip, or on a future CMOS chip for greater cost reduction.
University of Waterloo
200 University Ave W, Waterloo, ON
N2L 3G1
Phone: (519) 888-4567
Staff and Faculty Directory
Contact the Department of Electrical and Computer Engineering
The University of Waterloo acknowledges that much of our work takes place on the traditional territory of the Neutral, Anishinaabeg and Haudenosaunee peoples. Our main campus is situated on the Haldimand Tract, the land granted to the Six Nations that includes six miles on each side of the Grand River. Our active work toward reconciliation takes place across our campuses through research, learning, teaching, and community building, and is centralized within our Office of Indigenous Relations.