University of Waterloo
200 University Avenue West
Waterloo, Ontario, Canada N2L 3G1
Phone: (519) 888-4567 ext 32215
Fax: (519) 746-8115
Dr. Campbell leads a highly multidisciplinary research group where they study ocular development, eye disease, and linear and non-linear optics of the eye. They investigate the fundamental refractive properties of the eye's components to improve diagnosis and therapy for various ocular conditions.
Analysis of the blur of the optical image on the retina and factors influencing this blur. Maintenance of image quality with growth and accommodation. Presbyopia. Changes in optical quality of the eye following refractive surgery (PRK). Influence of optical blur on ophthalmic instrument performance. Improved optical diagnostic and therapeutic ophthalmic instrumentation.
Of particular interest is the gradient of refractive index within the crystalline lens of the eye and efforts have concentrated both on measuring this distribution and on modeling the resulting optical quality of the lens and eye. Maintenance of optical image quality during growth and accommodative changes is being investigated. A sophisticated optical design program (Code V) is used to predict optical image quality on the surface of the retina corresponding to different locations in the visual field, and to investigate the influence of the pupil and of optical component tilt and decentration.
The blur on the retina of the human eye is being measured using psychophysical methods and an improved objective Hartmann-Shack technique. Monochromatic aberrations (spherical aberration and coma) and longitudinal and transverse chromatic aberrations are measured using novel techniques. The influence of pupil size and position and accommodative state on image quality is being investigated. Conditions for optimal image quality for the viewing of structures in the eye are being investigated and instrumentation developed both to indicate the optimum and to improve image quality.
Future measurements will investigate the optical quality of the crystalline lens with age and as the ciliary muscle contracts to focus at near and resulting changes in the eye's optical image quality. Assessment of the type and amount of aberration present will allow the separation of the contributions of the optical elements and the pupil to optical quality. This will simplify the analysis of changes in optical quality with changes in pupil size, accommodative state and age. The first anatomically-based lens and eye models which accurately predict measured optical performance are currently being developed. An improved technique for measuring the optical quality of the eye will be used to assess the comparative performance of uncorrected eyes and eyes corrected with spectacles, contact lenses and surgery.
The influence of the optical quality of the eye on ophthalmic instrumentation is being explored and methods of improving the resolution of the eye-instrument combinations continue to be developed (including the use of adaptive optics). A new high resolution confocal scanning laser microscope/ophthalmoscope has been constructed and is being used to explore changes in the structures at the rear of the eye in the healthy eye and early in disease progression.
Vincent A, Wright T, Garcia-Sanchez Y, Kisilak ML, Campbell MCW, Westall C, Héon E. (2013) Phenotypic Characteristics Including In Vivo Cone Photoreceptor Mosaic in KCNV2-Related "Cone Dystrophy with Supernormal Rod Electroretinogram”. IOVS. 54(1), 898-908. Link
Campbell MCW, Bunghardt K, Kisilak ML, Irving EL. (2012) Diurnal Rhythms of Spherical Refractive Error, Optical Axial Length and Power in the Chick. IOVS, 53(10), 6245-53. Link
Kisilak ML, Bunghardt K, Hunter JJ, Irving EL, Campbell MCW (2012) Longitudinal in vivo imaging of cones in the alert chicken. Optom. Vis. Sci. 89(5), 644-51. Link
Hunter JJ, Campbell MCW, Kisilak ML, Irving EL (2009) Retinal blur in development: Comparison of eye growth models to experimental data. J. Vis. 9(6),12, 1-20. Link
Bueno JM, Cookson CJ, Kisilak ML, Campbell MCW (2009) Enhancement of confocal microscopy images using Mueller-matrix polarimetry. J. Microsc. 235(1), 84-93. Link
Please see Google Scholar for a complete list of Dr. Campbell's publications.
Dr. Campbell is a co-holder of several patents in Canada and the United States.
Campbell, M.C.W., 2010. Methods for imaging amyloid beta in the retina of the eye in association with Alzheimer’s disease. [US Provisional Patent ] Patent number 9,149,184, filed May 5, 2010 (issued, 2013).
Campbell, M.C.W., Bueno, J.M., 2007. Method and apparatus for improved fundus imaging through choice of light polarization. [International PCT and US Provisional Patent] Patent number 8,282,211, filed May 3, 2007 (issued, 2009); [European Regional Phase and US National Phase] Patent number 2009310083, filed December 17, 2009.
Bueno, J.M., Campbell, M.C.W., 2005. Method and apparatus for imaging using polarimetry and matrix based image reconstruction. [US Patent Office] Patent number 6,927,888, filed May 13, 2003, (issued, 2005); [Canadian Patent Office] Patent number 2,407,918, filed May 13, 2003 (issued, 2014).
Bueno, J.M., Campbell, M.C.W., 2002. Confocal scanning laser ophthalmoscopy using Mueller-matrix polarimetry. [US Provisional Patent].
The following news stories have featured Dr. Campbell's research:
1989 Postdoctorate in Mathematics and Statistics, Commonwealth Scientific and Industrial Research Organization, Melbourne, Victoria, Australia
1989 Postdoctorate in Physiology, Australian National University, Canberra, Australia
1982 PhD Applied Maths and Physiology, Australian National University, Canberra, Australia
1977 MSc Physics, University of Waterloo, Waterloo, Ontario, Canada
1975 BSc Chemistry and Physics, University of Toronto, Toronto, Ontario, Canada