Seminar | Rationally Designed Devices for Sensing and Manipulation of Biological Processes at the Nano Scale by Professor Zeinab Jahed

You're invited to join the Department of Chemical Engineering for a seminar by Professor Zeinab Jahed, assistant Professorof Nanoengineering at Jacobs School of Engineering, University of California, San Deigo

Abstract

The goal of our lab at the University of California, San Diego (called the Bio-Nano-Electronics or BioNE Lab) is to “Engineer nanoscale electronics for high-throughput cellular- and molecular-scale sensing, to accelerate scientific discoveries related to human health and disease”.  To design more intelligent nano-electronics for biological applications, we must first carefully study the complex nano-bio interface. Next, we can use this knowledge to design our nano-bioelectronics to be high throughput, accurate, sensitive, with minimal perturbations to the biological system. Finally, with confidence in our biological read-outs from these high-throughput tools, there is a need to develop algorithms that can “learn” from our big dataset to answer fundamental biological questions.

In this seminar I will begin by presenting our work on characterization of the nano-bio interface focusing on how cells respond to mechanical stimuli at the single cell and single molecule scales. I will provide insights into how mechanical signals such as micro- and nano-topography affect cell adhesion on metallic surfaces. Next, I will discuss how we have leveraged these insights to design non-invasive and high-throughput nano-electrode platforms for measuring electrical signals from hundreds to thousands of cells. Finally, I will briefly discuss our recent efforts to employ state of art artificial intelligence and machine learning techniques to decipher electrical signals obtained using our platform for applications in high-throughput drug discovery. 

Biographical Sketch

Dr. Zeinab Jahed is currently an Assistant Professor of Nanoengineering, at the Jacobs School of Engineering at the University of California, San Diego. She completed her Postdoctoral Research Fellowship in the department of Chemistry at Stanford University in 2020. She obtained her PhD in Applied Science and Technology at the University of California, Berkeley in the Departments of Mechanical and Bioengineering in 2018. Before moving to California, Dr. Jahed obtained her bachelor’s degree at the University of Waterloo in Canada, where she was affiliated with the departments of Mechanical and Mechatronics Engineering, and Chemical Engineering. Dr. Jahed's research is heavily multidisciplinary and spans several fields of engineering and biological sciences. Her research to date has resulted in 17 first author scientific journal publications and 22 co-authored papers in the multidisciplinary fields of experimental and computational biophysics and bioengineering. She has obtained several academic honors and awards. In 2018, she was named 1 of 24 recipients (top 0.05%) of Canada’s Banting Postdoctoral Fellowship, and ranked #1 nationally in the selection committee for Chemical, Biomedical and Material Science and Engineering in the Natural Sciences and Engineering Research Council of Canada (NSERC) Postdoctoral Fellowship competition. Other notable and recent awards include the University of California, Berkeley Applied Science & Technology Excellence in Research Award in 2018, and the University of California Cancer Research Coordinating Committee (CRCC) predoctoral fellowship award in 2017.

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