Seminar - “Biochemical Control of Phosphate Mineral Saturation: A Proposal for Polyphosphates” by Sidney Omelon, Assistant Professor, Chemical Engineering, University of Ottawa
ABSTRACT: The rigidity of our skeleton is due to reinforcement with nano-sized minerals of biological apatite. Theories of skeletal apatite nucleation include initiation by the organic matrix (collagen and non-collagenous proteins), and increasing the phosphate concentration by hydrolysis of phosphoric acid monoesters. An enzyme that has been attributed to skeletal mineralization - tissue-nonspecific alkaline phosphatase (TNAP) - is known to increase inorganic phosphate concentration by catalyzing phosphoric acid monoester hydrolysis. However, the substrate for TNAP in