Dr. Nekkar Rao specializes in medicinal and bioorganic chemistry; exploring rational drug design aided by molecular modelling techniques and small molecule synthetic organic/medicinal chemistry.
His work includes method development; solid phase peptide synthesis of bioactive peptides / peptidomimics; modern analytical techniques such as nuclear magnetic resonance spectroscopy, mass spectroscopy and high performance liquid chromatography; and development of high-throughput biochemical screening protocols to discover lead candidates.
Office: PHR 5002
Phone: 519-888-4567, ext.21317
Website: Medicinal and Bioorganic Chemistry Lab
- Drug Discovery
- Rational Drug Design & Medicinal Chemistry
- Cancer Therapy
- Treatment of Neurodegenerative Disorders
- Drug discovery/rational design
- Synthesis and biological evaluation of novel organic molecules and peptides/peptidomimics as therapeutic agents
For more information see Dr. Nekkar’s Research Website.
Dr. Nekkar teaches both undergraduate and graduate courses. Course offerings have included:
- PHARM 141 Introduction to Medicinal Chemistry, Toxicology and Pharmacology
- PHARM 220-223 Integrated Patient Focused Care 1-4
- PHARM 320-324 Integrated Patient Focused Care 5-8
- PHARM 603 Selected Topics in Medicinal Chemistry
- PHARM 607 Advanced Pharmaceutical Analysis
- PHARM 610 Topics in Drug Development
- Tarek Mohamed, Arash Shakeri, Praveen P. N. Rao, Structure-activity relationship studies of isomeric 2,4-diaminoquinazolines on β-amyloid aggregation kinetics. ACS Medicinal Chemistry Letters 7, 502-507 (2016), (Cover page article)
- Tarek Mohamed, Arash Shakeri, Praveen P. N. Rao, Amyloid cascade in Alzheimer's disease: recent advances in Medicinal Chemistry. European Journal of Medicinal Chemistry 113, 258-272 (2016)
- Tin G, Mohamed T, Gondora N, Beazely M. A. Praveen P N Rao Tricyclic phenothiazine and phenoselenazine derivatives as potential multi-targeting agents to treat Alzheimer’s disease. Medicinal Chemistry Communication 6, 1930-1941 (2015), (Cover page article)
- Xian-Le Bu, Praveen P N Rao, Yan-Jiang Wang. Anti-amyloid aggregation activity of natural compounds: Implications for Alzheimer's drug discovery. Molecular Neurobiology doi: 10.1007/s12035-015-9301-4, 2015.
- Liu H, Ojha B, Morris C, Jiang M, Wojcikiewicz E. P, Praveen P N Rao, Du D. Positively charged chitosan and N-trimethylchitosan inhibit Aβ40 fibrillogenesis. Biomacromolecules 16: 2363-2373, 2015.
- Tarek Mohamed, Tuan Hoang, Masoud Jelokhani-Niaraki, Praveen P N Rao. Tau-derived-hexapeptide 306VQIVYK311 aggregation inhibitors: Nitrocatechol moiety as a pharmacophore in drug design. ACS Chemical Neuroscience 4: 1559-1570, 2013.
- Ravinder Kodela, Mitali Chattopadhyay, Satindra Goswami, Zong, Yuan Gan, Praveen P N Rao, Kamran V Nia, Carlos A. Velázquez-Martínez, Khosrow Kashfi. Positional isomers of aspirin are equally potent in inhibiting colon cancer cell growth: Differences in mode of cyclooxygenase inhibition. Journal of Pharmacology and Experimental Therapeutics 345: 85-94, 2013.
- Praveen P N Rao, Qiao-Hong, Chen, Edward, E Knaus (2006). Synthesis and structure-activity relationship studies of 1,3-diphenylprop-2-yn-1-ones: Dual inhibitors of cyclooxygenases and lipoxygenases. Journal of Medicinal Chemistry 49: 1668-1683, 2006.
- Praveen P N Rao, Md. Jashim, Uddin, Edward, E Knaus. Design, synthesis and structure-activity relationship (SAR) studies of substituted-3,4,6-triphenylpyran-2-ones as selective cyclooxygenase-2 inhibitors. Journal of Medicinal Chemistry 47: 3972-3990, 2004.
- Indolizine derivatives, WO2013116948, 2013
Awards and Distinctions
- 2016 Outstanding Faculty Mentor in the Graduate Program
- 2015 Early Researcher Award, Ministry of Research, Innovation and Science, Government of Ontario
University of Waterloo Affiliations
- Cross-appointed to the Department of Biology and the Department of Chemistry in the Faculty of Science
Professional Associations and Service
The following news stories have featured Dr. Nekkar's research:
1995 BPharm (Manipal College of Pharmaceutical Sciences)
1998 MPharm (Manipal College of Pharmaceutical Sciences)
2004 PhD Pharmaceutical Science (University of Alberta)
2004-5 Postdoctoral Fellowship, Specialization in Medicinal Chemistry (University of Alberta)
2006-8 Postdoctoral Fellowship, Specialization in Medicinal Chemistry (The Scripps Research Institute)