Qing-Bin Lu

• Biophysics and biochemistry (molecular mechanisms of DNA damage and cell death)
• Femtochemistry, Femtobiology and Femtomedicine
• Cancer Therapies (chemotherapy, radiotherapy and photodynamic therapy; targeted therapy)
• Environmental/atmospheric science (theory of ozone depletion – the ozone hole)
• Climate research (theory of global climate change—“global warming”)
• Ultrafast laser spectroscopic techniques
• Nano-scale and atomic-scale surface science

The advent of femtosecond (1fs=10^-15 s) time-resolved laser spectroscopy made it possible to observe molecular reactions directly (femtochemistry), for which Professor Ahmed Zewail at Caltech (Lu’s former postdoctoral advisor) won the Nobel Prize in Chemistry in 1999.  Since 2004, Lu has applied this cutting-edge technique to study important biological processes in relation to diseases and their treatments, particularly in the field of oncology. This innovative approach has led to the creation of a brand-new research field, where the femtosecond time-resolved laser spectroscopy was successfully incorporated with molecular biology and cell biology methods to advance our understanding of human diseases and their treatments. Lu coined the term “femtomedicine” (FMD) on his breakthroughs in 2010 [QB Lu, Reviews in Mutation Research 704, 190–199(2010)]. Through his research in FMD, Lu has discovered a novel molecular mechanism of DNA damage and a new family of non-platinum-based halogenated molecules, called FMD compounds.  The latter have a unique molecular mechanism of action, generating a destroying effect in the intracellular environment of cancerous cells while having a protective effect on healthy/normal cells. FMD compounds therefore naturally and selectively target and kill cancer cells. They are effective in treating a variety of in vitro cancer cell lines and in vivo animal cancer models while exhibiting no systemic and radiation toxicities toward normal cells/tissues. These findings were recently published in the Cell Press and Lancet’s EBioMedicine, and in AACR’s Molecular Cancer Therapeutics. Lu is now translating findings arising from fundamental FMD studies into cancer therapies in the clinic. The success will lead to novel targeted chemotherapies and radiotherapies with minimal side effects and better targeting to treat a variety of cancers.

Lu also made important discoveries for the sciences underlying ozone depletion and global climate change. His theories have fundamentally challenged the previous “conclusions” by the Novel Prize winners in the formation of the ozone hole and global warming (1995 Nobel Chemistry and 2007 Novel Peace awards) and provided the best predictions that agree with up-to-date observations. His pioneering contributions were summarized in his monographic book entitled New Theories and Predictions of the Ozone Hole and Climate Change published recently by World Scientific Inc. (New Jersey, London, Singapore, Beijing, etc., 2015) pp.1-308.

• PHYS 359, Statistical Mechanics
• PHYS 395, Biophysics of Therapeutic Methods
• PHYS 234, Quantum Mechanics (I)
• PHYS 771, Special Topics in Biophysics

Lu, Q.B. and Sanche, L. Effects of Cosmic Rays on Atmospheric Chlorofluorocarbon Dissociation and Ozone Depletion. Phys. Rev. Lett. (87) 7, pp. 078501(1)-078501(4).

Wang, C.R., Nguyen, J. and Lu, Q.B. Bond Breaks of Nucleotides by Dissociative Electron Transfer of Nonequilibrium Prehydrated Electrons: A New Molecular Mechanism for Reductive DNA Damage. J. Am. Chem. Soc. (131) 32, pp. 11320-11322. 

Lu, Q.B. Cosmic-Ray-Driven Electron-Induced Reactions of Halogenated Molecules Adsorbed on Ice Surfaces: Implications for Atmospheric Ozone Depletion and Global Climate Change. Physics Reports (2010) 487, pp. 141-167.

Lu, Q.B., Zhang, Q.R., Ou, N., Wang, C.R. and Warrington, J.  In vitro and in vivo Studies of Non-Platinum-Based Halogenated Compounds as a New Class of Potent Antitumor Agents for Natural Targeted Chemotherapy of Cancers. EBioMedicine (2015) 2, pp. 544-553.

Wang, C.R., Mahmood, J., Zhang, Q.R., Vedadi, A., Warrington, J., Ou, N., Bristow, R.G., Jaffray, D.A., and Lu, Q.B., In Vitro and In Vivo Studies of a New Class of Anticancer Molecules for Targeted Radiotherapy of Cancer. Mol. Cancer Ther. (2016) 15, pp. 640-650. 

Please see Google Scholar for a complete list of Professor Lu's publications.

• 2014 to present, University Research Chair, University of Waterloo
• 2008-2013, New Investigator Award, Canadian Institute of Health Research (CIHR)
• 2007-2012, Early Researcher Award, Ontario's Ministry of Research and Innovation
• 2001-2006, Senior Research Fellowship (Phases I & II), Canadian Institute of Health Research (CIHR)

• Cross appointment, Department of Biology, University of Waterloo
• Cross appointment, Department of Chemistry, University of Waterloo

• 2012-present Canadian Institutes of Health Research, Peer Review Committee, member
• 2008-present      Member of the College of Reviewers for Canada Research Chairs program
• 2012-2013 Canadian Cancer Society Research Institute, Peer Review Committee, member
• 2012-2013 Terry Fox New Frontiers Program in Cancer, Peer Review Committee, member for Team Grant

Examples of news stories that have featured Professor Lu's research:

• July 2015: Press release by World Scientific, CFC most likely major driver of climate change, not CO2: Expert  and EurekAlert, CFCs most likely major driver of climate change, not CO2
• May 2015: Press release by Elsevier, Scientists discover new molecules that kill cancer cells and protect healthy cells; Press release by UW, Waterloo researcher discovers molecules that could kill cancer cells while protecting healthy cells; Waterloo researcher discovers promising cancer treatment; Scientists discover new molecules that kill cancer cells and protect healthy cells; Scientists identify new molecules that destroy cancer cells, save healthy ones
• May 31, 2013: Press release by UW, Global warming caused by CFCs, not carbon dioxide; Phys.org, Global warming caused by chlorofluorocarbons, not carbon dioxide, new study says; Wall Street Journal, Global warming and Ronald Reagan; Innovation Toronto, global warming caused by cfcs not carbon dioxide, study says
• June 2010: National Post, Global cooling underway
• December 21, 2009: Waterloo study shows CFCs, cosmic rays main culprits for global warming
• March 23, 2009: UW prof says cyclic ozone hole proves cosmic ray theory; CBC (Canada), New theory blames cosmic rays for helping CFCs deplete ozone
• August 2001: Ozone Layer Burned by Cosmic Rays, Physical Review Focus 8, 8; Scientific American, Study suggests cosmic rays may destroy ozone
• June 1999: ABC (Australia), Ozone hole to continue growing

1997 PhD Physics, University of Newcastle, Newcastle, New South Wales, Australia

1989 MSc Physics, The Chinese Academy of Science, Xicheng District, Beijing, China

1986 BSc Physics, Fuzhou University, Fuzhou, Fujian Province, China