MASc Oral Exam/ Analysis of Heterogeneities in a 20 L Bioreactor by Danny Kang

You are invited to Danny Kang's Oral Exam where he will discuss his research on Analysis of Heterogeneities in a 20 L Bioreactor.

Abstract:

Biological systems are essential in biopharmaceuticals, where rising demand requires efficient bioreactor operation. Scaling from lab to industry is limited by gradients from poor mixing, reducing yields through cell stress and adaptation. This work quantified dissolved oxygen, pH, and kLa gradients in a 20 L bioreactor. While cell density and metabolite gradients were inconclusive, metabolic responses were modelled with modified Monod kinetics, which adapted well to differing conditions.

Attend the virtual session.

Supervisors: Professor Marc Aucoin & Professor Hector Budman