Seminar - “Production of Polyglutamic Acid Nanoparticles for Controlled Release of Anti-Cancer Drugs” by Dr. Argyrios Margaritis, Professor of Biochemical Engineering, Dept. of Chemical and Biochemical Engineering, University of Western Ontario, London,ON
ABSTRACT: In this work we present results on the use of Gamma-Polyglutamic Acid (PGA) biopolymer to produce nanoparticles and encapsulate the anti-cancer drug Doxorubicin (DOX). Microbially produced PGA is used alone and in combination with Chitosan (CS) to form DOX-loaded nanoparticles at different conditions. The main mechanism of nanoparticle formation is the ionic complexation between PGA, DOX and CS.