Research interests
My cardiovascular research interests relate to regulation of blood vessel function and the signaling pathways in endothelial and vascular smooth muscle cells that control this function. In particular, I am interested in the effects of hypertension, age, and exercise on blood vessel health. Our recent work has focused on discovering regulatory influences on endothelium derived contracting factors, and on the effects of the red wine polyphenol resveratrol on vascular function. The ultimate goal of this research is to explain the mechanisms by which vascular function can be improved to prevent disease and the preserve cardiovascular health.
Teaching, expertise, tools and technologies
- Cardiovascular physiology
- Blood vessel health
- Endothelium
- Vascular smooth muscle
- Isolated blood vessels
- Endothelium-derived contracting and relaxing factors
- Resveratrol
- Prostanoids
- Vascular effects of exercise
Leadership
Past positions include:
- Vice-President, Academic and Provost, University of Waterloo
- Dean, Faculty of Health
- Associate Dean, Graduate Studies and Research, Faculty of Health
- Chair, Department of Kinesiology and Health Sciences
Education
BSc Human Kinetics (with distinction), University of Guelph
PhD Physiology (with distinction), State University of New York Health Sciences Centre Syracuse
MSc Human Biology, University of Guelph
Selected publications
See Google Scholar for list of publications.
*Denniss SG, * Ford RJ, * Smith CS, *Jeffery AJ, Rush, JWE. Chronic in vivo or acute in vitro resveratrol attenuates endothelium-dependent cyclooxygenase-mediated contractile signalling in hypertensive rat carotid artery. J Appl Physiol, 120: 1141-50, 2016. DOI: 10.1152/japplphysiol.00675.2015. PMID:26917696
*Ford RJ, *Teschke SR, *Reid EB, *Durham KK, *Kroetsch JT, Rush JWE. AMP-activated protein kinase activator AICAR acutely lowers blood pressure and relaxes isolated resistance arteries of hypertensive rats. Journal of Hypertension, 30: 725-733, 2012.
*Ford RJ, Rush JWE. Endothelium-dependent vasorelaxation to the AMPK activator AICAR is enhanced in aorta from hypertensive rats and is NO- and EDCF-dependent. Am J Physiol Heart Circ Physiol, 300: H64-H75, 2011.
Denniss SG, Jeffery AJ, Rush JWE. RhoA-Rho kinase signaling mediates endothelium- and endoperoxide-dependent contractile activities characteristic of hypertensive vascular dysfunction. Am J Physiol Heart Circ Physiol, 298: H1391-H1405, 2010.