Dr. Edginton’s research focuses on building virtual organisms to study the pharmacokinetics of drugs and environmental contaminants. Using pharmacokinetic (PBPK) models to provide a mechanistic means of understanding how changes in physiology can affect the absorption, metabolism and excretion of a chemical.
- Development and application of physiologically-based pharmacokinetic (PBPK) models and simulation techniques for the guidance of pharmaceutical dosing
Dr. Andrea Edginton’s research focuses on building virtual organisms to study the pharmacokinetics of drugs and environmental contaminants.; and using PBPK models to scale pharmacokinetics among species (e.g., from rat to human) and within a species (e.g., from healthy adults to children or patients) with an eye toward determining the right dose of medicine or determining differential risks associated with contaminant exposure in human health risk. Her research examines how the physiology of sub-populations, particularly children, affects the pharmacokinetics of drugs and how this information can be integrated into PBPK models for the optimization of drug therapy.
For more information see Dr. Edginton’s Research Group
Dr. Edginton teaches at both the graduate and undergraduate levels. Course offerings have included:
PHARM 220 Integrated Patient Focused Care 1
PHARM 224 Pharmacokinetic Fundamentals
PHARM 608A – Special Topics in Pharmaceutical Sciences – Pharmacokinetics
PHARM 609 Advanced Pharmacokinetics
Offman E, Edginton AN. 2015. A PBPK workflow for first-in-human dose selection of a subcutaneously administered pegylated peptide. Journal of Pharmacokinetics and Pharmacodynamics. 42(2):135-50
Maharaj A, Fotaki N, Edginton A. 2015. Parameterization of small intestinal water volume using PBPK modeling. European Journal of Pharmaceutical Science. 67:55-64.
McEneny-King A, Edginton AN, Rao PP. 2015. Investigating the binding interactions of the anti-Alzheimer's drug donepezil with CYP3A4 and P-glycoprotein. Bioorganic & Medicinal Chemistry Letters. 25(2):297-301.
Hu Z, Edginton AN, Laizure SC, Parker RB. 2014. Physiologically based pharmacokinetic modeling of impaired carboxylesterase-1 activity - Effects on oseltamivir disposition. Clinical Pharmacokinetics. 53(9): 825-836.
Yun YE, Cotton C, Edginton AN. 2014. Development of a decision tree to classify the most accurate tissue-specific tissue to plasma partition coefficient algorithm for a given compound. Journal of Pharmacokinetics and Pharmacodynamics. 41(1): 1-14.
Maharaj AR, Edginton AN. 2014. Physiologically based pharmacokinetic modeling and simulation in pediatric drug development. Clinical Pharmacology and Therapeutics: Pharmacometrics Systems Pharmacology. 3:e150.
- Willmann S, Edginton AN, Schmitt W. Verbessertes Verfahren zur zeitlich gesteuerten intravenösen Verabreichung des Narkosemittels Propofol (Improved method and technique for controlled intravenous administration of the sedative propofol). Systems Biology, Bayer Technology Services, Leverkusen, Germany. Wipo Patent WO/2006/133825 (date: 21.12.2006).
- Willmann S, Edginton AN, Hoehn K, Schmitt W. Verfahren zur Berechnung und Bereitstellung einer Medikamentendosis (Method for calculating and providing a drug dose - towards individualized dosing). Systems Biology, Bayer Technology Services, Leverkusen, Germany. Wipo Patent WO/2007/147539 (date: 27.12.2007).
Awards and Distinctions
2015 Outstanding Performance Award, University of Waterloo - The award recognizes the top 10 per cent of UW faculty.
2015 Excellence in Science Teaching Award, one of two Science Faculty members for 2015
2013 Outstanding Performance Award, University of Waterloo - The award recognizes the top 10 per cent of UW faculty.
University of Waterloo Affiliations
- Cross appointed to Department of Biology
Professional Associations and Service
Member of the Editorial Board, Therapeutic Drug Monitoring Journal (2009 – Present)
Chair of the Clinical Research Ethics Board at the University of Waterloo
The following news stories have featured Professor Edginton's research:
April 20, 2015: Andrea Edginton wins Excellence in Science Teaching Award
1998 BSc Environmental Biology (University of Guelph)
2004 PhD Environmental Toxicology (University of Guelph)