Department of Biology
200 University Ave. W
Canada N2L 3G1
Phone: (519) 888-4567 ext. 32569
Fax: (519) 746-0614
Niels Bols is best known for his remarkable generation and maintenance of cell lines for detailed experimental work.
He officially retired in 2013 and was designated as a Distinguished Professor Emeritus by the University of Waterloo in 2015.
- Cell line generation and maintence
- In vitro toxicology and biotechnology of animal cell cultures
- Roles of nutrition, hormones and polypeptide growth factors on the growth and differentiation of fish tissues and organs
Animal cell cultures are being used for three purposes: basic research, in vitro toxicology, and biotechnology. Basic research is being done on the development of differentiated fish cell lines and culture systems. These are used to identify and study the roles of nutrition, hormones and polypeptide growth factors on the growth and differentiation of fish tissues and organs.
A particular point of interest is hemopoiesis. In the future these factors may be useful in enhancing the growth and health of fish. Some of the cell lines are being used in ecotoxicology studies. In particular the toxicology of dioxin-like compounds and polycyclic aromatic (PAHs) is being investigated. Many of his projects used current recombinant DNA and immunological technologies.
Recent publications include
- Pham, P.H., Jung, J. and N.C. Bols. (2011). Using 96-well tissue culture polystyrene plates and fluorescence plate reader as tools to study the survival and inactivation of viruses on surfaces. Accepted to Cytotechnology.
- Kawano, A., Haiduk, C., Schirmer, K., Hanner, R., Lee, L.E.J., Dixon, B. and N.C. Bols. (2011). Development of a rainbow trout intestinal epithelial cell line and its response to lipopolysaccharide. Aquaculture Nutrition 17: e241-e252.
- St. Denis, C., Pinheiro, M.D., Power, M.E. and N.C. Bols. (2010). Effect of salt and urban water samples on bacterirvory by the ciliate, Tetrahymena thermophila. Environmental Pollution 158: 502-507.
Awards and Distinctions
- 2012 Outstanding Performance Award
- 1990 Distinguished Teacher Award
University of Waterloo Affiliations
- Centre for Bioengineering and Biotechnology
1970 BSc Simon Fraser
1972 MSc University of British Columbia
1975 PhD University of Toronto