MASc Oral Exam|Exploring the Cytoskeleton and Apoptosis Mechanisms in Fuchs Endothelial Corneal Dystrophy Using In Vitro Biomimetic Models and Immortalized FECD Cells by Fancheng Sun

In a closed session Fancheng Sun will discuss their research.

Abstract:

Fuchs endothelial corneal dystrophy (FECD) can lead to corneal blindness if untreated. A study to further explore the pathology of the FECD is needed. By utilizing an immortalized FECD corneal endothelial cell line FECD 54F and a biomimicking guttata model, we found that the FECD cells seeded on the guttata patterns have higher cytoskeleton contractility and apoptosis rate.

By employing a concave contact lens, we found that FECD 54F cells migrated faster than the B4G12 cells on the concave side of the gelatin methacrylate+.

Supervisor: Professor Evelyn Yim