News

Professor Valerie Ward is part of a new global coalition to revolutionize vaccine production with disruptive health technology. The technology is designed to enable local vaccine production, reducing production time from nine days to just one day. A breakthrough that has the potential to save millions of lives and significantly lower the cost of vaccine production.

A research coalition led by the Centre for Process Innovation (CPI) received $2.8 million from the Coalition of Epidemic Preparedness Innovation (CEPI) to fund technology development to combat epidemics and pandemics. The aim is to make small transportable units to manufacture vaccines, making vaccines more accessible and better able to deal with local outbreaks.

Ward is working with researchers and industry partners in Brazil, the UK, and Canada to aid the world in responding more swiftly and equitably to future epidemics and pandemics. 

The grant focuses on developing technology to meet two specific goals. The first is rapid production of vaccines. The second is to decentralize manufacturing so it can be produced at different sites in smaller batches.

Researchers in the Department of Chemical Engineering have developed a new method for engineering bacteria that can be leveraged to improve biomedical applications such as drug delivery, cancer therapy, anti-inflammatory treatments, and vaccine development.

The international research group, led by Professor Yilan Liu, developed a process that enables bacteria to secrete bacterial membrane vesicles (BMVs). BMVs are nanosized bubble-shaped structures naturally released by bacteria. They have significant potential as tools for the development of a variety of therapeutics.  

Currently, the adoption of BMVs has been hindered by low production yields under natural conditions. The technique established by Liu resulted in a 140-fold increase in the secretion of BMVs.

"This advancement in bacterial engineering has the potential to be a transformative platform for next-generation vaccines, therapeutics, and nutrient delivery," says Liu. "This new process could profoundly impact global health by making biomedical treatments more efficient, accessible, and affordable."

The Department of Chemical Engineering is proud to announce the appointment of Professor Evelyn Yim as an NSERC Canada Research Chair in Nanomaterials for Regenerative Medicine.

Yim has also been awarded over $ 1 million to conduct research focusing on understanding and enhancing microenvironments by controlling cell-nanostructure interactions for applications in regenerative medicine.

Her research examines how cells respond to biomaterials, focusing on 2D and 3D systems. The field of regenerative nanomedicine uses nanotechnology to repair or regenerate damaged tissue and organs. She uses principles of engineering and biological science to advance regenerative nanomedicine.

Offering promising solutions for a range of diseases

Yim’s research group is developing different types of nanofabrication materials to mimic natural nanostructures found in the human body to guide cell growth.

Yim conducts pioneering research in nanotopography, cell therapy, and improving the design of neural stem cells.  She has advanced innovations in tissue engineering for vascular and corneal disease.

Professor Milad Kamkar’s research group has developed the first all-graphene water-based ink for 3D printing via direct ink writing. The ink promises to unlock new possibilities for addressing environmental challenges, such as eliminating invisible electromagnetic pollution from our surroundings.

The eco-friendly graphene ink enables groundbreaking applications in advanced fields, including electromagnetic interference (EMI) shielding, electronics, and environmental protection while providing a scalable solution for next-generation 3D-printed technologies.

Graphene is a material renowned for its remarkable strength, electrical conductivity, and thermal properties. One of the challenges to the widespread utilization of graphene is that it is typically produced in powder form, which is difficult to handle and limits its full application potential.

Researchers overcame this barrier by precisely engineering the nano-scale surface chemistry of graphene nanosheets to make them dispersible in water, creating a room-temperature printable, eco-friendly ink.

Inspired by the movement of water striders cruising on the surface of water, a research group led by Professor Hamed Shahsavan have designed smart, soft microrobots whose movements can be controlled by light, offering exciting possibilities in environmental remediation and biomedical applications.

Imagine autonomous robots deployed to clean up microplastics in bodies of water. The research also has potential in biomedical applications. Microrobots could be guided inside the human body to conduct medical procedures.

“We’re moving toward smart swimming robots with more autonomous behaviour, by making them respond to external cues like light, or magnetic fields,” said Shahsavan, a professor in the Department of Chemical Engineering

Researchers at the University of Waterloo are taking a novel approach to tackle the critical issue of microplastic pollution in water systems. The research team is engineering bacteria that already exist in wastewater to break down Polyethylene terephthalate(PET).

Plastic waste in water systems is an urgent environmental concern. PET plastics degrade into microplastics that adversely impact the ecosystems of our lakes, rivers, and oceans.

Professor Marc Aucoin from the Department of Chemical Engineering and Professor Brian Ingalls from the Department of Applied Mathematics with PhD student Aaron Yip are developing a technique that enables wastewater bacteria to break the links between plastic molecules so PETs can be degraded.

Researchers at the University of Waterloo can now make eco-friendly plastics using bacteria that feed on food scraps from your table. Unlike animals that store fat when they consume excess food, these bacteria store a biopolymer. Biopolymers are natural polymers produced by the cells of living organisms that are fully biodegradable. The biopolymer can be used in multiple applications, including single-use plastics.  

Utilizing food waste is beneficial to the environment as it typically generates methane and carbon dioxide when decomposing in landfills, contributing to greenhouse gases. 

Plastics produced using this new method have many potential applications. For example, in food packaging as a plastic film to cover meat.

In 2023, Professors William Anderson and Marc Aucoin supervised preliminary research on concussion biomarkers found in bodily fluids, particularly saliva.

Exploring concussion biomarker research

Initially, Shazia Tanvir, a research associate of Anderson’s, began exploring research on concussion biomarkers. She was later introduced to Andrew Cordssen-David, who was a Master of Business, Entrepreneurship and Technology student at the Conrad School of Entrepreneurship and Business at the time.

Cordssen-David was also a former student-athlete who played for the varsity men’s hockey team at the University of Waterloo and had experienced his share of concussions. Recognizing the potential impact of a saliva-based concussion test, Cordssen-David and Tanvir got to work, committing themselves to developing a new concept for a saliva-based concussion screening tool.

A new study by researchers at the University of Waterloo has uncovered a crucial mechanism in the evolution of regulatory systems in E. coli that could have far-reaching applications in cancer therapy and biomanufacturing for products such as insulin or mRNA vaccines.

The critical insight arose when the research team examined a regulatory mechanism near the tail end of a protein called PykF

“A helpful analogy to understand this mechanism is the speedometer in a car. When you're driving through a town, where there are dangers to avoid, you need to know how fast you're going, so the speedometer is important. But, if you're on an open stretch of road with no risks, you can throw the speedometer out the window and put the pedal to the metal,” said Dr. Christian Euler from the Department of Chemical Engineering. “The research opens up the potential to one day put a new stoplight on the road to limit growth rate.”

Ever heard of the phrase coined by Friedrich Nietzsche, “the devil is in the details”? Professors William Anderson and Boxin Zhao have advanced the battle against microplastic pollution by uncovering the intricate details of how microplastics degrade in the environment. Observation and understanding the fine details of microplastics are key to eradicating them from our environment.

The research group has been able to observe the degradation of micro and nanoplastics with unprecedented detail. In collaboration with the National Research Council (NRC) researchers leveraged 3D imaging technology, which allows for a much deeper understanding of the microplastic degradation process than traditional 2D microscopy.

This detailed observation is the first of its kind, demonstrating the potential of 3D imaging as a powerful tool in microplastic research.