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Marc Aucoin

Associate Professor, Dir, Eng Professional Dev Prgm

Contact InformationMarc Aucoin

Phone: 519-888-4567 x36084,519-888-4567 x38835
Location: E6 4012,E6 4113

Website

Biography Summary

Marc Aucoin is an Associate Professor in the Department of Chemical Engineering. He specializes in Biochemical Engineering, particularly in cell culture engineering for the production of complex biologics: from proteins (projects have included work on myristoylated proteins, antibodies and other immune-system related proteins), to DNA, to virus-like particles, viruses and viral vectors.

Professor Aucoin’s research work makes use of several cell culture platforms including insect (Sf9, Hi5) and mammalian cells (CHO, Vero). One aspect of Prof. Aucoin's work involves the use of 1D-1H NMR for optimizing cell culture processes.

Through his work with viruses, Prof. Aucoin has also gained an interest in examine the stability of virus in complex solutions including cell culture media. This has led to collaborations with industry in the area of virus inactivation and virus control.

At the University, Prof. Aucoin is the Academic Director of WatPD Engineering. He is also a Faculty Advisor for the university’s international Genetically Engineered Machine (iGEM) competition student team. Prof. Aucoin is an active member of the Centre for Bioengineering and Biotechnology (https://uwaterloo.ca/bioengineering-biotechnology/) and the Waterloo Centre for Microbial Research (https://uwaterloo.ca/waterloo-centre-microbial-research/).

Research Interests

  • Viral Vector
  • Virus-like Particle
  • Vaccine Production
  • Infection
  • Gene Delivery
  • Animal Cell Culture
  • Biochemical & Biomedical
  • Mammalian Cell
  • Metabolism
  • Bioprocess Development
  • Monoclonal Antibody Production And Modification
  • Baculovirus Bioprocessing
  • Biologic Production In Insect Cells Using Baculovirus Expression Vectors
  • Cell Culture Monitoring
  • Modeling And Simulation
  • Monoclonal Antibody Production And Modification
  • Nanotechnology

Education

  • 2007, Doctorate, Chemical Engineering, Ecole Polytechnique de Montreal
  • 2003, Master's, Chemical Engineering, University of Waterloo
  • 2000, Bachelor's, Chemical Engineering, University of Waterloo

Courses

  • CHE 562 - Advanced Bioprocess Engineering
    • Taught in 2013, 2014, 2016
  • BME 184 - Engineering Biology
    • Taught in 2015
  • BME 184L - Engineering Biology Laboratory
    • Taught in 2015
  • CHE 360 - Bioprocess Engineering
    • Taught in 2013, 2014, 2015
  • CHE 660 - Principles of Biochemical Engineering
    • Taught in 2016
  • CHE 765 - Research Topics in Biochemical Engineering
    • Taught in 2014, 2015, 2016, 2017, 2018

Selected/Recent Publications

  • Meunier, Sarah M and Todorovic, Biljana and Dare, Emma V and Begum, Afroza and Guillemette, Simon and Wenger, Andrew and Saxena, Priyanka and Campbell, J Larry and Sasges, Michael and Aucoin, Marc G, Impact of Dissolved Oxygen during UV-Irradiation on the Chemical Composition and Function of CHO Cell Culture Media, PloS one, 11(3), 2016
  • Thompson, Christine M and Montes, Johnny and Aucoin, Marc G and Kamen, Amine A, Recombinant Protein Production in Large-Scale Agitated Bioreactors Using the Baculovirus Expression Vector System, Baculovirus and Insect Cell Expression Protocols, 2016, 241 - 261
  • Thompson, Christine M and Aucoin, Marc G and Kamen, Amine A, Production of Virus-Like Particles for Vaccination, Baculovirus and Insect Cell Expression Protocols, 2016, 299 - 315
  • Aucoin, Marc, Fluorescent influenza-like particles and control over their composition, , 2016
  • Pyne, Michael E and Sokolenko, Stanislav and Liu, Xuejia and Srirangan, Kajan and Bruder, Mark R and Aucoin, Marc G and Moo-Young, Murray and Chung, Duane A and Chou, C Perry, Disruption of the reductive 1, 3-propanediol pathway triggers production of 1, 2-propanediol for sustained glycerol fermentation by Clostridium pasteurianum, Applied and Environmental Microbiology, 2016