Marc G. Aucoin

Professor & Chair (Interim)

Contact InformationMarc G. Aucoin

Phone: 519-888-4567 x36084,519-888-4567 x38835,519-888-4567 x32295
Location: E6 4012,E6 4113,E6 3036

Website

Biography Summary

Marc Aucoin is a Professor in the Department of Chemical Engineering. He specializes in Biochemical Engineering, particularly in cell culture engineering for the production of complex biologics: from proteins (projects have included work on myristoylated proteins, antibodies and other immune-system related proteins), to DNA, to virus-like particles, viruses and viral vectors.

Professor Aucoin’s research work makes use of several cell culture platforms including insect (Sf9, Hi5) and mammalian cells (CHO, Vero). One aspect of Prof. Aucoin's work involves the use of 1D-1H NMR for optimizing cell culture processes.

Through his work with viruses, Prof. Aucoin has also gained an interest in examining the stability of virus in complex solutions including cell culture media. This has led to collaborations with industry in the area of virus inactivation and virus control.

At the University, Prof. Aucoin is the Interim Chair for Chemical Engineering. He is also a Faculty Advisor for the university’s international Genetically Engineered Machine (iGEM) competition student team. Prof. Aucoin is an active member of the Centre for Bioengineering and Biotechnology and the Waterloo Centre for Microbial Research. He is also a member of the Waterloo Institute for Nanotechnology. More information can be found on his personal website.

Research Interests

  • Virus propagation
  • Viral vector
  • Virus-like particle
  • Vaccine production
  • Infection
  • Gene delivery
  • Animal cell culture
  • Biochemical & Biomedical
  • Mammalian cell
  • Metabolism
  • Bioprocess development
  • Monoclonal Antibody Production and Modification
  • Biologic Production
  • Baculovirus Expression Vectors
  • Serological Assays
  • Cell Culture Monitoring
  • Modeling and Simulation
  • Synthetic Biology

Education

  • 2007, Doctorate, Chemical Engineering, Ecole Polytechnique de Montreal
  • 2003, Master's, Chemical Engineering, University of Waterloo
  • 2000, Bachelor's, Chemical Engineering, University of Waterloo

Courses*

  • BME 285 - Engineering Biology
    • Taught in 2018
  • CHE 180 - CHE Design Studio 1
    • Taught in 2019, 2020
  • CHE 202 - Seminar
    • Taught in 2020
  • CHE 299 - Directed Research Project
    • Taught in 2020
  • CHE 301 - Seminar
    • Taught in 2020
  • CHE 398 - Directed Research Project
    • Taught in 2020
  • CHE 401 - Seminar
    • Taught in 2020
  • CHE 498 - Directed Research Project
    • Taught in 2020
  • CHE 499 - Elective Research Project
    • Taught in 2020
  • CHE 500 - Spec. Topics in CHE Engr'g
    • Taught in 2020
  • CHE 562 - Advanced Bioprocess Eng
    • Taught in 2016, 2019, 2020
  • CHE 660 - Biochemical Engineering
    • Taught in 2016, 2019
  • CHE 765 - Res Tpcs in Biochemical Eng.
    • Taught in 2016, 2017, 2018, 2019, 2020
* Only courses taught in the past 5 years are displayed.

Selected/Recent Publications

  • Moussa, Hassan I and Chan, Wing Y and Logan, Megan and Aucoin, Marc G and Tsui, Ting Y, Limitation in Controlling the Morphology of Mammalian Vero Cells Induced by Cell Division on Asymmetric Tungsten-Silicon Oxide Nanocomposite, Materials, 13(2), 2020
  • Walji, Sadru-Dean and Aucoin, Marc G, A critical evaluation of current protocols for self-sterilizing surfaces designed to reduce viral nosocomial infections, American Journal of Infection Control, 2020
  • Shafiee, Fatemeh and Aucoin, Marc G and Jahanian Najafabadi, Ali, Targeted Diphtheria Toxin Based Therapy: A Review Article, Frontiers in microbiology, 10, 2019
  • Tsui, Ting Y and Logan, Megan and Moussa, Hassan I and Aucoin, Marc G, What’s Happening on the Other Side? Revealing Nano-Meter Scale Features of Mammalian Cells on Engineered Textured Tantalum Surfaces, Materials, 12(1), 2019
  • Logan, Megan and Manalil, Julia and Notte, Christina and Kearse, Craig and George, Steve and Zeiser, Arno and Farrell, Patrick and Aucoin, Marc G, A flow cytometric granularity assay for the quantification of infectious virus, Vaccine, 37(47), 2019, 7090 - 7099
  • Gabriel, Michelle A and Dare, Emma V and Meunier, Sarah M and Campbell, J Larry and Sasges, Michael R and Aucoin, Marc G, Ultraviolet irradiation of trypsin, lysozyme and β-galactosidase: how does UVC affect these enzymes when used as a secondary barrier against adventitious agents?, Vaccine, 37(43), 2019, 6518 - 6525
  • Moussa, Hassan I and Logan, Megan and Wong, Kingsley and Rao, Zheng and Aucoin, Marc G and Tsui, Ting Y, Nanoscale-Textured Tantalum Surfaces for Mammalian Cell Alignment, Micromachines, 9(9), 2018
  • Yen, Sandi and Bolte, Erin and Aucoin, Marc and Allen-Vercoe, Emma, Metabonomic Evaluation of Fecal Water Preparation Methods: The Effects of Ultracentrifugation, Current Metabolomics, 6(1), 2018, 57 - 63

In the News

Graduate Studies