Marc Aucoin is a Professor in the Department of Chemical Engineering. He specializes in Biochemical Engineering, particularly in cell culture engineering for the production of complex biologics: from proteins (projects have included work on myristoylated proteins, antibodies and other immune-system related proteins), to DNA, to virus-like particles, viruses and viral vectors.
Professor Aucoin’s research work makes use of several cell culture platforms including insect (Sf9, Hi5) and mammalian cells (CHO, Vero). One aspect of Prof. Aucoin's work involves the use of 1D-1H NMR for optimizing cell culture processes.
Through his work with viruses, Prof. Aucoin has also gained an interest in examining the stability of virus in complex solutions including cell culture media. This has led to collaborations with industry in the area of virus inactivation and virus control.
At the University, Prof. Aucoin is the Interim Chair for Chemical Engineering. He is also a Faculty Advisor for the university’s international Genetically Engineered Machine (iGEM) competition student team. Prof. Aucoin is an active member of the Centre for Bioengineering and Biotechnology and the Waterloo Centre for Microbial Research. He is also a member of the Waterloo Institute for Nanotechnology. More information can be found on his personal website.
- Virus propagation
- Viral vector
- Virus-like particle
- Vaccine production
- Gene delivery
- Animal cell culture
- Biochemical & Biomedical
- Mammalian cell
- Bioprocess development
- Monoclonal Antibody Production and Modification
- Biologic Production
- Baculovirus Expression Vectors
- Serological Assays
- Cell Culture Monitoring
- Modeling and Simulation
- Synthetic Biology
- 2007, Doctorate, Chemical Engineering, Ecole Polytechnique de Montreal
- 2003, Master's, Chemical Engineering, University of Waterloo
- 2000, Bachelor's, Chemical Engineering, University of Waterloo
- Moussa, Hassan I and Chan, Wing Y and Logan, Megan and Aucoin, Marc G and Tsui, Ting Y, Limitation in Controlling the Morphology of Mammalian Vero Cells Induced by Cell Division on Asymmetric Tungsten-Silicon Oxide Nanocomposite, Materials, 13(2), 2020
- Walji, Sadru-Dean and Aucoin, Marc G, A critical evaluation of current protocols for self-sterilizing surfaces designed to reduce viral nosocomial infections, American Journal of Infection Control, 2020
- Gabriel, Michelle A and Dare, Emma V and Meunier, Sarah M and Campbell, J Larry and Sasges, Michael R and Aucoin, Marc G, Ultraviolet irradiation of trypsin, lysozyme and β-galactosidase: how does UVC affect these enzymes when used as a secondary barrier against adventitious agents?, Vaccine, 37(43), 2019, 6518 - 6525
- Shafiee, Fatemeh and Aucoin, Marc G and Jahanian Najafabadi, Ali, Targeted Diphtheria Toxin Based Therapy: A Review Article, Frontiers in microbiology, 10, 2019
- Tsui, Ting Y and Logan, Megan and Moussa, Hassan I and Aucoin, Marc G, What’s Happening on the Other Side? Revealing Nano-Meter Scale Features of Mammalian Cells on Engineered Textured Tantalum Surfaces, Materials, 12(1), 2019
- Logan, Megan and Manalil, Julia and Notte, Christina and Kearse, Craig and George, Steve and Zeiser, Arno and Farrell, Patrick and Aucoin, Marc G, A flow cytometric granularity assay for the quantification of infectious virus, Vaccine, 37(47), 2019, 7090 - 7099
- Yen, Sandi and Bolte, Erin and Aucoin, Marc and Allen-Vercoe, Emma, Metabonomic Evaluation of Fecal Water Preparation Methods: The Effects of Ultracentrifugation, Current Metabolomics, 6(1), 2018, 57 - 63
- Moussa, Hassan I and Logan, Megan and Wong, Kingsley and Rao, Zheng and Aucoin, Marc G and Tsui, Ting Y, Nanoscale-Textured Tantalum Surfaces for Mammalian Cell Alignment, Micromachines, 9(9), 2018