University of Waterloo
200 University Avenue West
Waterloo, Ontario, Canada N2L 3G1
Phone: (519) 888-4567 ext 32215
Fax: (519) 746-8115
Dr. Leonenko leads a nanoscale biophysics research group which uses advanced scanning probe microscopy methods to study biophysics of lipids and lipid-protein interactions, interactions of nanoparticles with lipid membrane and monolayers, and to develop novel application of lipid films in biomedical nanotechnology and biosensing.
Scanning Probe Microscopy (SPM) methods, including atomic force microscopy, provide a powerful way for imaging and manipulations of matter at the nanoscale and are especially useful in life sciences and bionanotechnology. Professor Leonenko’s research program employs SPM methods to study biophysics of lipids and lipid-protein interactions, the role of structural changes and physical properties of lipid template in controlling biological processes and diseases.
Amyloid fibrils are insoluble protein aggregates that associated with several neurodegenerative diseases such as Alzheimer’s disease. Professor Leonenko’s research team studies the structure and physical properties of the model and cell membrane in relation amyloid fibril formation and toxicity. These studies will aid in understanding of complex mechanism of amyloidoses and will help to develop novel methods for early detection and prevention of Alzheimer’s disease.
Professor Leonenko’s research group will also investigate the following:
Cordova G., Lee B., Leonenko, Z. Magnetic Force Microscopy for Nanoparticle Characterization. NanoWorld Journal (1) 2, pp. 10-14.
Liu, G., Zhao, S., Henderson, R., Leonenko, Z., Abdel-Rahman, E., Mi, Z., Ban, D. Nanogenerators Based on Vertically Aligned InN Nanowires. Nanoscale (4) 8, pp. 2097-2106.
Hane, F., Hayes, R., Lee, B., Leonenko, Z. Effect of Copper and Zinc on the Single Molecule Self-Affinity of Alzheimer's Amyloid-β Peptides. PLoS ONE (1) 11, pp. e0147488
Robinson, M., Lee, B., Leonenko, Z. Drugs and Drug Delivery Systems Targeting Amyloid-β in Alzheimers Disease. AIMS Molecular Science (3) 2, pp. 332-358.
Hagedorn, S., Drolle, E., Lorentz, H., Srinivasan, S., Leonenko, Z., Jones, L. Atomic Force Microscopy and Langmuir-Blodgett Monolayer Technique to Assess Contact Lens Deposits and Human Meiban Extracts. Journal of Optometry (3) 8, pp. 187-199.
Please see Google Scholar for a complete list of Professor Leonenko's publications.
2013-present, European Network on Applications of Atomic Force Microscopy to NanoMedicine and Life Sciences, member
2013-present, European Biophysical Societies Association member
2013-present, Canadian Chemical Society, member
1996 PhD Chemical Physics, Institute of Chemical Kinetics and Combustion, Russian Academy of Sciences, Novosibirsk, Russia
1985 MSc Chemical Physics, Novosibirsk State University, Russia Institute of Solid State Chemistry, Russian Academy of Sciences, Novosibirsk, Russia
1985 BSc Chemical Physics, Novosibirsk State University, Russia Institute of Solid State Chemistry, Russian Academy of Sciences, Novosibirsk, Russia
The University of Waterloo acknowledges that much of our work takes place on the traditional territory of the Neutral, Anishinaabeg and Haudenosaunee peoples. Our main campus is situated on the Haldimand Tract, the land granted to the Six Nations that includes six miles on each side of the Grand River. Our active work toward reconciliation takes place across our campuses through research, learning, teaching, and community building, and is centralized within our Indigenous Initiatives Office.