Discovery in bacterial evolution could improve cancer therapy and biomanufacturing
A new study by researchers at the University of Waterloo has uncovered a crucial mechanism in the evolution of regulatory systems in E. coli that could have far-reaching applications in cancer therapy and biomanufacturing for products such as insulin or mRNA vaccines.
The critical insight arose when the research team examined a regulatory mechanism near the tail end of a protein called PykF
“A helpful analogy to understand this mechanism is the speedometer in a car. When you're driving through a town, where there are dangers to avoid, you need to know how fast you're going, so the speedometer is important. But, if you're on an open stretch of road with no risks, you can throw the speedometer out the window and put the pedal to the metal,” said Dr. Christian Euler from the Department of Chemical Engineering. “The research opens up the potential to one day put a new stoplight on the road to limit growth rate.”