Study sheds light on how mechanical stress contributes to corneal disease
Professor Evelyn Yim’s research group advances the understanding and potential treatment of Fuchs endothelial corneal dystrophy (FECD), a leading cause of blindness and corneal transplants.
Alternatives to surgical transplants, such as injecting healthy cells directly into the eye or using medication, are urgently needed due to a shortage of donor corneas.
The cornea is a clear, dome-shaped protective membrane at the front of the eye, and its transparency is essential for vision.
FECD results in the formation of tiny bumps on the innermost surface of the cornea. These bumps cause the progressive loss of human corneal endothelial cells (HCECs) that act as pumps, constantly clearing excess fluid from the cornea to keep it transparent.
When the cornea becomes cloudy, the condition is in an advanced stage. The study aims to understand the disease mechanism to develop better alternative treatments.