Associate Professor

Contact InformationEvelyn Yim

Phone: 519-888-4567 x33928
Location: E6 4014

Website

Biography Summary

Evelyn Yim joined the Department of Chemical Engineering as an Associate Professor at the University of Waterloo in 2016. Experienced with nanofabrication technologies and stem cell culture, Evelyn and her Regenerative Nanomedicine Lab group are interested to apply the knowledge biomaterial-stem cell interaction to direct stem cell differentiation and tissue regeneration for neural, vascular and corneal tissue engineering. Evelyn is one of the pioneers in studying stem cell-topography interactions and related applications in tissue engineering. She is one of the leading researchers studying the use of synthetic materials for altering stem cell behavior and differentiation.

Evelyn Yim began her education at the University of Toronto, where she earned her BASc in Engineering Science and MASc in Chemical Engineering, under the supervision of Professor Michael Sefton. She pursued her PhD in Biomedical Engineering at Johns Hopkins University before conducting her post-doctoral training at the Johns Hopkins School of Medicine and, under Professor Kam Leong, in the Department of Biomedical Engineering at Duke University.

Between 2007 and 2015 Evelyn worked in Singapore, where she held a joint appointment from the National University of Singapore, as faculty in the departments of Biomedical Engineering and Surgery, and the Mechanobiology Institute Singapore, a Research Center of Excellence supported by the National Research Foundation Singapore, as a principle investigator studying how chemical and biomechanical cues influence stem cell behavior.

Research Interests

  • Modulation of cell behaviour with nanotopography
  • Topography-regulation of stem cells lineage commitment and differentiation
  • Differentiation of adult and plutipotent stem cells with nanotopography
  • Fabrication and application of nano-structure for biomedical applications in neural
  • vascular and cornea tissue engineering
  • Biomaterial approach to study ex-vivo pluripotent stem cell expansion
  • Nanotechnology
  • Biochemical engineering
  • Biomedical engineering

Education

  • 2006, Doctorate, Biomedical Engineering, Johns Hopkins School of Medicine
  • 2000, Master of Engineering, Chemical Engineering, University of Toronto
  • 1999, Bachelor of Applied Science, Engineering Science, University of Toronto

Courses*

  • CHE 760 - Special Topics in Biochemical Engineering
    • Taught in 2016, 2017, 2018
  • CHE 725 - Research Topics in Analysis of Chemical Processes
    • Taught in 2017
  • BME 489 - Special Topics in Biomedical Devices
    • Taught in 2019
  • NE 489 - Special Topics in Nanoscale Biosystems
    • Taught in 2016, 2017, 2018, 2019
  • NE 481 - Nanomedicine and Nanobiotechnology
    • Taught in 2018, 2019
* Only courses taught in the past 5 years are displayed.

Selected/Recent Publications

  • Jeong, YeJin and Yao, Yuan and Yim, Evelyn KF, Current understanding of intimal hyperplasia and effect of compliance in synthetic small diameter vascular grafts, Biomaterials Science, 8(16), 2020, 4383 - 4395
  • Rizwan, Muhammad and Chan, Sarah W and Comeau, Patricia A and Willett, Thomas L and Yim, Evelyn KF, Effect of sterilization treatment on mechanical properties, biodegradation, bioactivity and printability of GelMA hydrogels, Biomedical Materials, 2020
  • Arora, Seep and Lin, Shiming and Cheung, Christine and Yim, Evelyn KF and Toh, Yi-Chin, Topography elicits distinct phenotypes and functions in human primary and stem cell derived endothelial cells, Biomaterials, 234, 2020
  • Tse, John W and Rizwan, Muhammad and Rasmussen, Jonathan and Jones, Lyndon and Yim, Evelyn KF, Gelatin Methacrylate as an Enzyme-Controlled Release Vehicle of Hyaluronic Acid for the Treatment of Recurrent Corneal Erosion, ACS Applied Bio Materials, 3(9), 2020, 6214 - 6223
  • Yao, Yuan and Zaw, Aung Moe and Anderson, Deirdre EJ and Hinds, Monica T and Yim, Evelyn KF, Fucoidan functionalization on poly (vinyl alcohol) hydrogels for improved endothelialization and hemocompatibility, Biomaterials, 2020
  • Jain, Deepak and Mattiassi, Sabrina and Goh, Eyleen L and Yim, Evelyn KF and others, Extracellular matrix and biomimetic engineering microenvironment for neuronal differentiation, Neural regeneration research, 15(4), 2020
  • Pohan, Grace and Mattiassi, Sabrina and Yao, Yuan and Zaw, Aung Moe and Anderson, Deirdre EJ and Cutiongco, Marie FA and Hinds, Monica T and Yim, Evelyn KF, Effect of Ethylene Oxide Sterilization on Polyvinyl Alcohol Hydrogel Compared with Gamma Radiation, Tissue Engineering Part A, 2020
  • Rizwan, Muhammad and Yao, Yuan and Gorbet, Maud B and Tse, John W and Anderson, Deirdre EJ and Hinds, Monica T and Yim, Evelyn KF, One-Pot Covalent Grafting of Gelatin on Poly (Vinyl Alcohol) Hydrogel to Enhance Endothelialization and Hemocompatibility for Synthetic Vascular Graft Applications, ACS Applied Bio Materials, 3(1), 2019, 693 - 703
  • Son, Young Ju and John, W Tse and Zhou, Yiran and Mao, Wei and Yim, Evelyn KF and Yoo, Hyuk Sang, Biomaterials and controlled release strategy for epithelial wound healing, Biomaterials science, 7(11), 2019, 4444 - 4471
  • Xia, Shumin and Lim, Ying Bena and Zhang, Zhen and Wang, Yilin and Zhang, Shan and Lim, Chwee Teck and Yim, Evelyn KF and Kanchanawong, Pakorn, Nanoscale Architecture of the Cortical Actin Cytoskeleton in Embryonic Stem Cells, Cell reports, 28(5), 2019, 1251 - 1267
  • Xia, Shumin and Yim, Evelyn KF and Kanchanawong, Pakorn, Molecular organization of integrin-based adhesion complexes in mouse Embryonic Stem Cells, ACS Biomaterials Science & Engineering, 5(8), 2019, 3828 - 3842
  • Koh, Li Buay and Zuo, Keping and Kumar, Gideon Praveen and Ding, Xin and Leo, Hwa Liang and Cui, Fangsen and Charles, Christopher J and Yang, Yi-Yan and Yim, Evelyn KF and Ho, Pei, Optimization of a Novel Preferential Covered Stent through Bench Experiments and in Vitro Platelet Activation Studies, ACS Biomaterials Science & Engineering, 5(11), 2019, 6216 - 6230
  • Pohan, Grace and Chevallier, Pascale and Anderson, Deirdre and Tse, John and Yao, Yuan and Hagen, Matthew W and Mantovani, Diego and Hinds, Monica and Yim, Evelyn KF, Luminal Plasma Treatment for Small Diameter Polyvinyl Alcohol Tubular Scaffolds, Frontiers in Bioengineering and Biotechnology, 7, 2019
  • Anderson, Deirdre EJ and Pohan, Grace and Raman, Jaishankar and Konecny, Filip and Yim, Evelyn KF and Hinds, Monica T, Improving Surgical Methods for Studying Vascular Grafts in Animal Models, Tissue Engineering Part C: Methods, 24(8), 2018, 457 - 464
  • Ankam, Soneela and Teo, Benjamin Kim Kiat and Pohan, Grace and Ho, Shawn Wei Loong and Lim, Choon Kiat and Yim, Evelyn KF, Temporal changes in nucleus morphology, lamin A/C and histone methylation during nanotopography-induced neuronal differentiation of stem cells, Frontiers in Bioengineering and Biotechnology, 6, 2018
  • Tan, Kenneth KB and Lim, Wallie Wee Meng and Chai, Chou and Kukumberg, Marek and Lim, Kah Leong and Goh, Eyleen LK and Yim, Evelyn KF, Sequential application of discrete topographical patterns enhances derivation of functional mesencephalic dopaminergic neurons from human induced pluripotent stem cells, Scientific reports, 8(1), 2018, 1 - 13
  • Zeng, Yukai and Wong, Sum Thai and Teo, Soo Kng and Leong, Kam W and Chiam, Keng-Hwee and Yim, Evelyn KF, Human mesenchymal stem cell basal membrane bending on gratings is dependent on both grating width and curvature, Scientific reports, 8, 2018
  • Kukumberg, Marek and Yao, Yuan and Goh, Seok Hong and Neo, Dawn JH and Yao, Jia Yi and Yim, Evelyn KF, Evaluation of the Topographical Influence on the Cellular Behavior of Human Umbilical Vein Endothelial Cells, Advanced Biosystems, 2(6), 2018
  • Yip, Ai Kia and Nguyen, Anh Tuan and Rizwan, Muhammad and Wong, Sum Thai and Chiam, Keng-Hwee and Yim, Evelyn KF, Anisotropic traction stresses and focal adhesion polarization mediates topography-induced cell elongation, Biomaterials, 181, 2018, 103 - 112
  • Nguyen, Anh Tuan and Mattiassi, Sabrina and Loeblein, Manuela and Chin, Eunice and Ma, DongLiang and Coquet, Philippe and Viasnoff, Virgile and Teo, Edwin Hang Tong and Goh, Eyleen L and Yim, Evelyn KF, Human Rett-derived neuronal progenitor cells in 3D graphene scaffold as an in vitro platform to study the effect of electrical stimulation on neuronal differentiation, Biomedical Materials, 13(3), 2018
  • Cutiongco, Marie FA and Chua, Bryan MX and Neo, Dawn JH and Rizwan, Muhammad and Yim, Evelyn KF, Functional differences between healthy and diabetic endothelial cells on topographical cues, Biomaterials, 153, 2018, 70 - 84
  • Rizwan, Muhammad and Peh, Gary SL and Ang, Heng-Pei and Lwin, Nyein Chan and Adnan, Khadijah and Mehta, Jodhbir S and Tan, Wui Siew and Yim, Evelyn KF, Sequentially-crosslinked bioactive hydrogels as nano-patterned substrates with customizable stiffness and degradation for corneal tissue engineering applications, Biomaterials, 120, 2017, 139 - 154
  • Kukumberg, Marek and Yao, Jia Yi and Neo, Dawn JH and Yim, Evelyn KF, Microlens topography combined with vascular endothelial growth factor induces endothelial differentiation of human mesenchymal stem cells into vasculogenic progenitors, Biomaterials, 131, 2017, 68 - 85
  • Sathe, Sharvari and Chan, Xiang Quan and Jin, Jing and Bernitt, Erik and Döbereiner, Hans-Günther and Yim, Evelyn KF, Correlation and Comparison of Cortical and Hippocampal Neural Progenitor Morphology and Differentiation through the Use of Micro-and Nano-Topographies, Journal of functional biomaterials, 8(3), 2017
  • Rizwan, Muhammad and Peh, Gary S and Adnan, Khadijah and Naso, Sacha L and Mendez, Alon R and Mehta, Jodhbir S and Yim, Evelyn KF, Cell Therapy: In Vitro Topographical Model of Fuchs Dystrophy for Evaluation of Corneal Endothelial Cell Monolayer Formation (Adv. Healthcare Mater. 22/2016), Advanced Healthcare Materials, 5(22), 2016, 2960 - 2960
  • Cutiongco, Marie FA and Goh, Seok Hong and Aid-Launais, Rachida and Le Visage, Catherine and Low, Hong Yee and Yim, Evelyn KF, Planar and tubular patterning of micro and nano-topographies on poly (vinyl alcohol) hydrogel for improved endothelial cell responses, Biomaterials, 84, 2016, 184 - 195
  • Nguyen, Anh Tuan and Sathe, Sharvari R and Yim, Evelyn KF, From nano to micro: topographical scale and its impact on cell adhesion, morphology and contact guidance, Journal of Physics: Condensed Matter, 28(18), 2016
  • Cutiongco, Marie FA and Kukumberg, Marek and Peneyra, Jonnathan L and Yeo, Matthew S and Yao, Jia Yi and Rufaihah, Abdul Jalil and Le Visage, Catherine and Ho, Jackie Pei and Yim, Evelyn KF, Sub-millimeter diameter poly (vinyl alcohol) vascular graft patency in rabbit model, Frontiers in Bioengineering and Biotechnology, 4, 2016
  • Tan, Kenneth KB and Tann, Jason Y and Sathe, Sharvari R and Goh, Seok Hong and Ma, Dongliang and Goh, Eyleen LK and Yim, Evelyn KF, Enhanced differentiation of neural progenitor cells into neurons of the mesencephalic dopaminergic subtype on topographical patterns, Biomaterials, 43, 2015, 32 - 43
  • Muhammad, Rizwan and Peh, Gary SL and Adnan, Khadijah and Law, Jaslyn BK and Mehta, Jodhbir S and Yim, Evelyn KF, Micro-and nano-topography to enhance proliferation and sustain functional markers of donor-derived primary human corneal endothelial cells, Acta biomaterialia, 19, 2015, 138 - 148
  • Tan, Kenneth KB and Giam, Christine SY and Leow, Ming Yi and Chan, Ching Wan and Yim, Evelyn KF, Differential Cell Adhesion of Breast Cancer Stem Cells on Biomaterial Substrate with Nanotopographical Cues, Journal of Functional Biomaterials, 6(2), 2015, 241 - 258
  • Ankam, Soneela and Lim, Choon Kiat and Yim, Evelyn KF, Actomyosin contractility plays a role in MAP2 expression during nanotopography-directed neuronal differentiation of human embryonic stem cells, Biomaterials, 47, 2015, 20 - 28