Contact Info
Department of Applied Mathematics
University of Waterloo
Waterloo, Ontario
Canada N2L 3G1
Phone: 519-888-4567, ext. 32700
Fax: 519-746-4319
PDF files require Adobe Acrobat Reader
MC 6460
Thomas Hillen | Department of Mathematical and Statistical Science, University of Alberta
Mathematical Modeling of the Immune-Mediated Theory of Metastasis
Accumulating experimental and clinical evidence suggests that the immune response to cancer is not exclusively anti-tumor. In fact, several pro-tumor effects of the immune system have been identified, such as production of growth factors, establishment of angiogenesis, inhibition of immune response, initiation of cell movement and metastasis, and establishment of metastatic niches. Based on experimental data, we develop a mathematical model for the immune-mediated theory of metastasis, which includes anti- and pro-tumor effects of the immune system. The immune-mediated theory of metastasis can explain dormancy of metastasis and metastatic blow-up after resection of the primary tumor. It can explain increased metastasis at sites of injury, and the relatively poor performance of Immunotherapies, due to pro-tumor effects of the immune system.
Our results suggest that further work is warranted to fully elucidate and control the pro-tumor effects of the immune system in metastatic cancer. (with Adam Rhodes)
Contact Info
Department of Applied Mathematics
University of Waterloo
Waterloo, Ontario
Canada N2L 3G1
Phone: 519-888-4567, ext. 32700
Fax: 519-746-4319
PDF files require Adobe Acrobat Reader
The University of Waterloo acknowledges that much of our work takes place on the traditional territory of the Neutral, Anishinaabeg and Haudenosaunee peoples. Our main campus is situated on the Haldimand Tract, the land granted to the Six Nations that includes six miles on each side of the Grand River. Our active work toward reconciliation takes place across our campuses through research, learning, teaching, and community building, and is co-ordinated within the Office of Indigenous Relations.