Applied Mathematics Seminar | Michael Vynnycky, PAT-oriented asymptotic modelling for pharmaceutical freeze-dryingExport this event to calendar

Tuesday, January 31, 2017 2:30 PM EST

MC 6460<--break-><--break->

Speaker

Dr. Michael Vynnycky
Department of Material Science and Engineering | KTH Royal Institute of Technology

Title

PAT-oriented asymptotic modelling for pharmaceutical freeze-drying

Abstract

Freeze-drying (lyophilization) is a multi-stage process - typically, freezing, primary drying and secondary drying - that is widely used in the food and pharmaceutical industries to remove water, or another solvent, from heat-sensitive products that would potentially be damaged by the higher temperature of conventional drying treatments. The process is time-consuming and expensive; hence, modelling offers a route towards a better understanding of the process dynamics, its influence on the cycle time and the quality of the final product. Although multi-dimensional numerical models already exist, these are computationally too expensive in the context of a growing need to use models to monitor and control freeze-drying processes, termed soft sensor process analytical technology (PAT). Here, we see how "old-fashioned" nondimensionalization and asymptotic reduction does a reasonable job of delivering a computationally efficient model for describing the primary drying stage and the onset to secondary drying.

S M T W T F S
25
26
27
28
29
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
1
2
3
4
5
6
  1. 2024 (55)
    1. May (3)
    2. April (5)
    3. March (18)
    4. February (15)
    5. January (14)
  2. 2023 (96)
    1. December (6)
    2. November (11)
    3. October (7)
    4. September (8)
    5. August (12)
    6. July (5)
    7. June (6)
    8. May (5)
    9. April (14)
    10. March (7)
    11. February (8)
    12. January (7)
  3. 2022 (106)
  4. 2021 (44)
  5. 2020 (32)
  6. 2019 (86)
  7. 2018 (70)
  8. 2017 (72)
  9. 2016 (76)
  10. 2015 (77)
  11. 2014 (67)
  12. 2013 (49)
  13. 2012 (19)
  14. 2011 (4)
  15. 2009 (5)
  16. 2008 (8)