Elisabeth Prince

Assistant Professor, Chemical Engineering

Research interests: Soft matter, Biomimetic hydrogels, Filamentous hydrogels, Hydrogel mechanics, Injectable hydrogels, Tissue engineering, Biomedical engineering, Polymer synthesis, Polymer self-assembly, Sustainable plastics
Chemical recycling of plastics


Biography 

Elisabeth Prince
Elisabeth Prince joined the Department of Chemical Engineering at the University of Waterloo in January 2023. Her research interests lie at the interface of soft matter design, polymer chemistry, biomimetic materials, and sustainability.

Elisabeth started her education at the University of Toronto, where she received her undergraduate degree in Biological Chemistry. In 2021 she received her Ph.D. in Polymer and Materials Chemistry from the University of Toronto under the supervision of Professor Eugenia Kumacheva. During her Ph.D., she designed nanostructured hydrogels that mimic the architecture and mechanical properties of native biological tissues. In collaboration with the Princess Margaret Cancer Center, she developed new hydrogel matrices for growing patient-derived microtumors, which are an emerging platform for developing personalized cancer therapies.

After completing her Ph.D., she was an NSERC Postdoctoral Fellow in Professor Jeremiah Johnson’s synthetic polymer chemistry group at the Massachusetts Institute of Technology, where she pivoted her research interests towards addressing the plastic waste crisis. She developed new chemistry for recycling vinylic plastics and thermosets during her time at MIT.

At the University of Waterloo, Elisabeth’s group will build on her polymer and materials science expertise to design the molecular architecture of polymer networks, including hydrogels, elastomers, and thermosets. They will develop biomimetic hydrogels for applications in tissue engineering and in-vitro modeling of disease. They will also develop new tools for addressing the global plastic waste crisis.

Education

  • 2021, Doctorate, Polymer and Materials Chemistry, University of Toronto
  • 2016, Honours Bachelor of Science, Biological Chemistry Specialist, University of Toronto

RESEARCH

Biomimetic filamentous hydrogels

The extracellular matrix (ECM) is a network of branching protein nanofibers that acts as a scaffold for cells in biological tissues. The Prince Lab designs synthetic hydrogels that mimic the filamentous architecture of the ECM. Using these materials, they are studying the fundamental relationship between the structure of filamentous biomaterials and their mechanics, mass transport, and biological function.

Injectable filamentous hydrogels

Injectable biomimetic hydrogels have tremendous therapeutic potential in drug delivery and regenerative medicine. The Prince Lab develops polymers that will assemble into a biomimetic filamentous network after injection into the human body. They are interested in applying these materials to repair damaged tissues and for the delivery drugs and vaccines.

Chemistry for recycling plastics

Dr. Prince’s team is developing new chemical tools to help Canada meet its goal of reaching zero plastic waste by 2030. In particular, network plastics like rubbers and thermosets are very challenging to degrade and recycle. The Prince Lab are developing novel chemical approaches that will allow for the temperature-driven recycling of thermosets and rubbers. They will also study how the molecular architecture of plastics impacts their degradability.

PUBLICATIONS

  • Prince, Elisabeth; Cruickshank, Jennifer; Ba-Alawi, Wail; Hodgson, Kelsey; Haight, Jillian; Tobin, Chantal; Wakeman, Andrew; Avoulov, Alona; Topolskaia, Valentina; McGuigan, Alison P.; Berman, Hal K.; Haibe-Kains, Benjamin; Cescon, David W.; Kumacheva, Eugenia. 'Biomimetic hydrogel supports initiation and growth of patient-derived breast tumor organoids.’ Nature Communications, 13, 1-12, (2022).
  • Kiel, Gavin; Lundberg, David; Prince, Elisabeth; Husted, Keith; Johnson, Alayna; Lensch, Valerie; Li, Sipei; Shieh, Peyton; Johnson, Jeremiah. 'Cleavable comonomers for chemically circular polystyrene.’ Journal of the American Chemical Society. 144, 12979-12988 (2022).
  • Li, Yang; Li, Yunfeng; Prince, Elisabeth; Weitz, Jeffrey I.; Panyukov, Sergey; Ramachandran, Arun; Rubinstein, Michael; Kumacheva, Eugenia. 'Fibrous Hydrogels under biaxial confinement’ Nature Communications. Accepted on May 17, 2022.
  • Prince, Elisabeth; Wang, Yihe; Xu, Fei; Kheiri, Sina; Cruikshank, Jennifer; Topolskaia, Valentina; Tao, Huachen; Young, Edmund W. K.; McGuigan, Alison P.; Cescon, David; Kumacheva, Eugenia. 'Microfluidic arrays of patient-derived breast tumor spheroids as in-vitro models for personalized drug testing.’ Advanced Healthcare Materials, e2101085 (2021).
  • Prince, Elisabeth; Chen, Zhengkun; Khuu, Nancy; Xu, Fei; Kumacheva, Eugenia. 'Nanofibrillar hydrogel mimics structural changes associated with fibrosis of the extracellular matrix.’ Biomacromolecules, 22, 2352-2362 (2021). Front Cover.
  • Prince, Elisabeth; Kumacheva, Eugenia. 'Design and applications of man-made biomimetic fibrillar hydrogels’, Nature Reviews Materials, 4, 99–115, (2019).
  • Prince, Elisabeth; Alizadehgiashi, Moien; Campbell, Melissa; Khuu, Nancy; Albulescu, Alexandra; De France, Kevin; Ratkov, Dimitrije; Li, Yunfeng; Hoare, Todd; Kumacheva, Eugenia. 'Patterning of structurally anisotropic composite hydrogel sheets.’ Biomacromolecules, 19, 1276-1248 (2018).
  • Li, Yunfeng; Prince, Elisabeth; Sangho, Cho; Salari, Ali; Golestani, Youssef M.; Lavrentovich, Oleg D.; Kumacheva, Eugenia. 'Periodic assembly of nanoparticle arrays in disclinations of cholesteric liquid crystals.’ Proc. Nat. Acad. Sci. USA. 114, 2137-2142, (2016).
  • Li, Yunfeng; Suen, Jeffery; Prince, Elisabeth; Larin, Egor; Klinkova, Anna; Thérien-Aubin, Héloїse; Zhu, Shou jun; Yang, Bai; Helmy, Amr; Lavrentovich, Oleg D.; Kumacheva, Eugenia. 'Colloidal cholesteric liquid crystal in spherical confinement.’ Nature Communications, 7, 12520, (2016).

Please see Elisabeth Prince's Google Scholar profile for a current list of his peer-reviewed articles.

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