Peter Levine

Professor, Electrical and Computer Engineering

Research interests: bioelectronic systems laboratory; CMOS biochips for biomolecular and cellular assays; biodiagnostic devices for single molecule detection

Biography

Professor Peter M. Levine received the B.Eng. in Computer Engineering and M.Eng. in Electrical Engineering from McGill University in 2002 and 2004, respectively. In 2009 he obtained the Ph.D. in Electrical Engineering (with Distinction) at Columbia University. His doctoral work focused on the design of active CMOS biochips for label-based and label-free electrochemical DNA assays. He has held internship positions at Nortel Networks, Matrox, and Intel's Circuit Research Laboratory. From 2009 to 2010 he worked as a Research Engineer in integrated circuit and sensor design for the biotechnology firm Ion Torrent in Guilford, CT (now part of Life Technologies), which commercialized the first semiconductor-based genome sequencer. In 2011 he joined the Department of Electrical and Computer Engineering at the University of Waterloo. His research interests include CMOS-integrated biochemical assays and integrated microsystems for clinical and environmental monitoring. He was a recipient of the Intel Foundation Ph.D. Fellowship in 2005.

Education

PhD, Electrical Engineering, Columbia University, 2009
MEng, Electrical Engineering, McGill University, 2004
BEng, Computer Engineering, McGill University, 2002

Peter Levine

Research

Research Interests

CMOS-integrated biochemical assays
Integrated microsystems for clinical and environmental monitoring
Combining CMOS integrated circuits with novel materials, structures, or devices to enable non-traditional life science and bio-diagnostic applications

Publications

Journal Articles

D. L. Bellin, H. Sakhtah, J. K. Rosenstein, P. M. Levine, J. Thimot, K. Emmett, L. E. P. Dietrich, and K. L. Shepard, "Integrated circuit-based electrochemical sensor for spatially resolved detection of redox-active metabolites in biofilms," Nature Communications, vol. 5, no. 3256, Feb. 10, 2014, doi: 10.1038/ncomms4256.
P. M. Levine, P. Gong, R. Levicky, and K. L. Shepard, "Multiplexed, real-time electrochemical DNA detection using an active CMOS biosensor array with integrated sensor electronics," Biosensors and Bioelectronics, vol. 24, no. 7, pp. 1995-2001, Mar. 2009.
P. M. Levine, P. Gong, R. Levicky, and K. L. Shepard, "Active CMOS sensor array for electrochemical biomolecular detection," IEEE Journal of Solid-State Circuits, vol. 43, no. 8, pp. 1859-1871, Aug. 2008.
P. M. Levine and G. W. Roberts, "High-resolution flash time-to-digital conversion and calibration for system-on-chip testing," IEE Proceedings on Computers and Digital Techniques, vol. 152, no. 3, pp. 415-426, May 2005.

Conference Proceedings (Refereed)

M. M. R. Ibrahim and P. M. Levine, "CMOS transimpedance amplifier for biosensor signal acquisition," accepted to Proceedings of the IEEE International Symposium on Circuits and Systems (ISCAS), Melbourne, Australia, June 1-5, 2014.
K. A. Jensen, V. C. Gaudet, and P. M. Levine, "Noise analysis and measurement of integrator-based sensor interface circuits for fluorescence detection in lab-on-a-chip applications," Proceedings of the International Conference on Noise and Fluctuations (ICNF), Montpellier, France, 2013, doi: 10.1109/ICNF.2013.6578905.
C. O'Sullivan, P. M. Levine, and S. Garg, "Vertically-addressed test structures (VATS) for 3D IC variability and stress measurements," Proceedings of the IEEE International Symposium on Quality Electronic Design (ISQED), Santa Clara, CA, Mar. 2013, pp. 96-103.
P. M. Levine, P. Gong, K. L. Shepard, and R. Levicky, "Active CMOS array for electrochemical sensing of biomolecules,"Proceedings of the IEEE Custom Integrated Circuits Conference, Sept. 2007, pp. 825-828.
P. M. Levine and G. W. Roberts, "A high-resolution flash time-to-digital converter and calibration scheme," Proceedings of the International Test Conference, Oct. 2004, pp. 1148-1157.
P. M. Levine and G. W. Roberts, "A calibration technique for a high-resolution flash time-to-digital converter," Proceedings of the IEEE International Symposium on Circuits and Systems (ISCAS), May 2004, pp. 253-256.

Book Chapters

P. M. Levine, P. Gong, R. Levicky, and K. L. Shepard, "Active CMOS biochip for electrochemical DNA assays," in Microfluidics and Nanotechnology: Biosensing to the Single Molecule Limit, E. Lagally and K. Iniewski, Eds. New York: Taylor & Francis, 2014 (to appear).
P. M. Levine and G. W. Roberts, "High-resolution flash time-to-digital conversion and calibration for system-on-chip testing,"Embedded Microelectronic Systems: Status and Trends, B. M. Al-Hashimi, Ed. London: IEE Press, 2006.

Posters and Abstracts

P. M. Levine, P. Gong, R. Levicky, and K. L. Shepard, "Quantitative, real-time electrochemical DNA detection using an active CMOS biosensor array," Semiconductor Research Corporation (SRC) TECHCON, Austin, TX, Nov. 2008.
P. M. Levine, P. Gong, R. Levicky, and K. L. Shepard, "Real-time electrochemical DNA detection using an active integrated circuit biosensor array," Biomedical Engineering Society (BMES) Annual Fall Meeting, St. Louis, MO, Oct. 2008.

Book Reviews

P. M. Levine and K. L. Shepard, Review of "Handbook of Biosensors and Biochips," Eds. R. E. Marks, D. C. Cullen, I. Karube, C. R. Lowe, and H. H. Weetall, Chichester: Wiley, 2007, IEEE Signal Processing Magazine vol. 26, no. 1, pp. 146-147, Jan. 2009.

Patents

P. M. Levine, K. L. Shepard, P. Gong, and R. Levicky, "Active CMOS sensor array for electrochemical biomolecular detection," International Patent Application PCT/US08/87773, filed Dec. 19, 2008.