Waterloo Institute for Nanotechnology
Mike & Ophelia Lazaridis Quantum-Nano Centre, QNC 3606
University of Waterloo
200 University Avenue West,
Waterloo, ON N2L 3G1
519-888-4567, ext. 38654
win-office@uwaterloo.ca
Research interests: novel bacteriophage nanomedicines for the development of novel vaccines; pharmaceuticals and gene delivery systems
Professor Roderick Slavcev specializes in bacteriophage (phage) and molecular biology with experience in both academic and industrial settings. Prior to gathering valuable marketing and clinical experience as a medical liaison for the pharmaceutical industry he completed his post-doctoral fellowship at the Department of Medical Genetics and Microbiology at the University of Toronto in the area of bacteriophage P1 plasmid partition and chromosomal segregation. His current research group comprises Mediphage Bioceuticals (MB) and encompasses phage-based solutions with the ultimate aim of bringing new treatments to the global environment, especially less developed countries. MB research projects focus on the exploitation of bacteriophages and this rich genetic reservoir in the design and construction of synthetic biological production platforms. MB exploits coliphages and phage-encoded genes and genetic elements to design and construct vectors for the development of novel vaccines, targeted gene therapy systems, and the identification and application of novel phage genomic anti-bacterial genes to treat and dispose of the clinical culprits of global bacterial infection.
Post-Doctoral Fellow, University of Toronto
PhD, Microbial Genetics, University of Saskatchewan
MBA, Biotechnology Management and Commercialization, University of Saskatchewan
HBSc, University of Toronto
Research projects in the Slavcev lab focus on the production and characterization of novel bacteriophage (phage)-based nanomedicines and include the use of coliphages and filamentous phages in the design and construction of vectors for the development of novel vaccines, pharmaceuticals and gene delivery systems. Current projects include:
Further information on our research can be found at www.mediphage.ca.
Figures
Nafissi, N., Alqawlaq, S., Lee, E., Spagnuolo, P., Foldvari, M. and R.A. Slavcev*. 2014. Ministring DNA: Highly Safe and Effective DNA Transgene Delivery Vectors. Molecular Therapy Nucleic Acids (In Press)
Sum, C., Chong, J., Wettig, S. and R.A. Slavcev*. 2014. Purification of Linear Covalently Closed (LCC) DNA Ministrings by Q-Anion Exchange Membrane Chromatography. Chromatography A 1339: 214-218.
Nafissi, N., Sum, C., Wettig, S. and R.A. Slavcev* 2014. Optimization of a one-step inducible in vivo mini DNA vector production system. PLOS One 9: e89345.
Nicastro, J., Sheldon, K., and R.A. Slavcev*. 2014. Phage Display Applications. Applied Microbiology and Biotechnology98: 2853-66.
Nafissi, N., and R.A. Slavcev*. 2014. Bacteriophage recombination systems and biotechnological applications.Applied Microbiology and Biotechnology 98: 2841-51.
Nicastro, J., Sheldon, K., El-zarkout, F., Sokolenko, S., Aucoin, M., and R.A. Slavcev*. 2013. Construction and analysis of a genetically tuneable lytic phage display system. Applied Microbiology and Biotechnology 97:7791-7804.
Nafissi, N., and R.A. Slavcev*. 2012. Construction and Characterization of an in vivo linear covalently closed DNA vector production system. Microbial Cell Factories 11: 154-167.
Sokolenko, S., Nicastro, J., Slavcev, R.A., and M. Aucoin*. 2012. Graphical analysis of flow cytometer data for characterizing controlled fluorescent protein display on λ phage. Cytometry A 81: 1031-1039.
Kaur, T., Nafissi, N., Wasfi, O., Sheldon, K., Wettig, S., and R.A. Slavcev*. 2012. Immunocompatibility of Bacteriophages as Nanomedicines. Journal of Nanotechnology, 2012: 1-13.
Slavcev, R.A.*, Nafissi, N., and T. Kaur. 2012. SSINCC: Simple Separation of Interacting Nucleoprotein Complex Components. Advances in Biological Chemistry 2: 146-151.
R.A. Slavcev*. 2012. The Disparity of Motivational Drivers in International Health Care Systems. Pharmaceutical Regulatory Affairs 1: 1-2.
Huang, E. and R.A. Slavcev*. 2013. A Celebration of the Innovation and Entrepreneurship at University of Waterloo 2nd Annual Business Awards Ceremony. Canadian Pharmacists Journal/Revue des Pharmaciens du Canada 146: 251-252.
Slavcev, R.A.* Cheung, D., and J. Tjendra. 2013. A needs-driven model for strategic pharmacy education. Currents in Pharmacy Teaching and Learning 5: 593-599.
Slavcev, R.A.*, Tjendra, J., Boran, V. and N. Kanji. 2013. Pharmacy Investment Club: Fostering financial management skills from beyond the classroom. Canadian Pharmacists Journal/Revue des Pharmaciens du Canada 146: 144-145.
Slavcev, R.A.*, and A. Patel. 2012. Industrial Case Competition: Where Healthcare Interfaces Innovation.CPJ/RPC 145: 251.
Tjendra, J., Slavcev, R.A.*, and M. Stanley. 2012. University of Waterloo celebrates innovation and entrepreneurship.Canadian Pharmacists Journal/Revue des Pharmaciens du Canada 145:6-7.
Kaur, T., and R.A. Slavcev*. 2013. Solid Lipid Nanoparticles: “Tuneable Anti-Cancer Gene/Drug Delivery Systems”. In:Gene Therapy/Book 1, InTech Open Access Publisher.
Slavcev, R. and J. Nicastro. 2014. A Fine-tuned Lytic Phage Display System. USPTO serial #: 61/815467 (Under Review)
Slavcev, R. and N. Nafissi. 2014. In vivo linear covalently closed DNA vector production system. USPTO serial #: 61/729,384 (Under Review)
Office: PHR 4003
Phone: 519-888-4567, ext.21301
Email: slavcev@uwaterloo.ca
Website: Roderick Slavcev
Waterloo Institute for Nanotechnology
Mike & Ophelia Lazaridis Quantum-Nano Centre, QNC 3606
University of Waterloo
200 University Avenue West,
Waterloo, ON N2L 3G1
519-888-4567, ext. 38654
win-office@uwaterloo.ca
The University of Waterloo acknowledges that much of our work takes place on the traditional territory of the Neutral, Anishinaabeg and Haudenosaunee peoples. Our main campus is situated on the Haldimand Tract, the land granted to the Six Nations that includes six miles on each side of the Grand River. Our active work toward reconciliation takes place across our campuses through research, learning, teaching, and community building, and is co-ordinated within the Office of Indigenous Relations.