The President and Vice Chancellor is the administrative head of the College, overseeing all aspects of the institution. When the Chancellor is absent, the President and Vice-Chancellor fulfills the Chancellor's ceremonial roles. On January 25, 2017 the official title of Principal and Vice-Chancellor changed to President and Vice-Chancellor.
At Renison, the President and Vice-Chancellor's academic robes are red with silver braiding.
President and Vice-Chancellor of Renison
| The Rev. Dr. Marc Jerry | 2024-present |
Former Renison Presidents and Principals
| The Rev. Canon Dr. Wendy L. Fletcher | 2014-2024 (title changed from Principal to President in 2017) |
| Dr. Glenn F. Cartwright | 2009-2014 |
| Dr. Robert G. Rosehart | 2008-2009 (Interim) |
| Dr. John E. Crossley | 2002-2008 |
| Dr. M. Darrol Bryant | 1997 (Acting) |
| Dr. Gail P. Cuthbert Brandt | 1992-2002 |
| Prof. Ian L. Campbell | 1977-1992 |
| Dr. John O. Towler | 1974-1977 |
| Dr. Donald G.S. M'Timkulu | 1971-1974 (Acting) |
| Prof. A. Wyn Rees | 1961-1971 |
| The Rev. Canon C.C.W. Mixer | 1959-1961 (Acting) |