**Contact Info**

Department of Applied Mathematics

University of Waterloo

Waterloo, Ontario

Canada N2L 3G1

Phone: 519-888-4567, ext. 32700

Fax: 519-746-4319

PDF files require Adobe Acrobat Reader

Monday, April 10, 2023 2:00 PM EDT

MC 5479

Suzan Farhang-Sardroodi, Department of Mathematics, University of Manitoba, Centre for Disease Modelling (CDM), Mathematics Statistics, York University, Modelling Infection and Immunity Lab, Mathematics Statistics, York University

Machanistic mathematical modelling of the within-host response: from chemotherapy to COVID-19

Mechanistic modelling approaches and pharmacological considerations play a decisive role in exploring novel treatment modalities in cancer and infectious diseases. The recent expansion of within-host mathematical models addresses many questions regarding effective cancer treatments as well as the complex interplay of virus replication and the behaviour of host immune response. Mathematical models have become an integral part of systems biology, which can describe known physiology and fill in the gaps in our understanding of which complex interactions drive host-pathogen responses.

In this seminar, I will first present our mathematical model developed in the context of cancer chemotherapy to define an optimal treatment schedule that reduces tumour burden while also maintaining lean muscle mass. Although chemotherapy is the most common cancer treatment, it has significant side effects, including muscle atrophy. Preservation of body composition, in addition to consideration of inflammation and immune interactions, the gut microbiome, and other systemic health measures, may lead to improved patient-specific treatment plans that improve patient quality of life. Next, I will discuss recent work focused on using mathematical modelling to identify biological and COVID-19 vaccine characteristics that may allow for heightened and longer-lasting immune responses. Here, we focused on the optimal timing of second doses as supply chain logistics hampered initial global vaccine delivery, which is impacted mass vaccination strategies during the early phases of mass vaccination in the COVID-19 pandemic. I will present our recent study which aimed to predict the impact of different prime-boost schedules by quantifying their effects on immunological outcomes based on a simple system of ordinary differential equations.

Event tags

**Contact Info**

Department of Applied Mathematics

University of Waterloo

Waterloo, Ontario

Canada N2L 3G1

Phone: 519-888-4567, ext. 32700

Fax: 519-746-4319

PDF files require Adobe Acrobat Reader

University of Waterloo

University of Waterloo

43.471468

-80.544205

200 University Avenue West

Waterloo,
ON,
Canada
N2L 3G1

The University of Waterloo acknowledges that much of our work takes place on the traditional territory of the Neutral, Anishinaabeg and Haudenosaunee peoples. Our main campus is situated on the Haldimand Tract, the land granted to the Six Nations that includes six miles on each side of the Grand River. Our active work toward reconciliation takes place across our campuses through research, learning, teaching, and community building, and is co-ordinated within the Office of Indigenous Relations.