Applied Math Seminar | Donghoon Lee, Life Virtualization Technology: L++ Programming for Efficient and Scalable Biosystem Design.

MC 6460

Speaker

Donghoon Lee, University of Texas Southwestern

Title

Life Virtualization Technology: L++ Programming for Efficient and Scalable Biosystem Design.

Abstract

Genome is the blueprint for life, consisting of four nucleic acid bases that cells read and process. However, it is challenging for humans to directly interpret or modify the genome without annotation. We have developed L++, a comprehensive programming language specifically designed for biologists to unambiguously describe, design, execute, analyze, and debug large-scale biological systems, including organisms. We decoupled biology from computation and introduced intuitive syntax and grammar that can be learned in less than a day, making it accessible to individuals with minimal traditional computer programming experience. L++ features modular programming and includes essential traditional programming functions to enable efficient biology programming. Using L++, we are writing E. coli code, which integrates research from an array of heterogeneous databases and resources. It can be used and repurposed through simulations and visualizations to efficiently create biochemical pathways, reprogram cells, and design and eventually create organisms. Our ultimate goal is to reverse-engineer our knowledge of biology to reconstruct and execute human code, enabling full-scale systematic analysis and debugging of human diseases. With L++, we aim to facilitate the discovery of novel treatments and therapies, transforming the way we approach human health.