Contact Info
Department of Applied Mathematics
University of Waterloo
Waterloo, Ontario
Canada N2L 3G1
Phone: 519-888-4567, ext. 32700
Fax: 519-746-4319
PDF files require Adobe Acrobat Reader
AMATH Grad Students
Stephanie Abo | University of Waterloo
Modelling fuel metabolism during exercise in men and women
Women oxidize significantly more lipids and significantly less carbohydrates than men during endurance exercise. This sexual dimorphism in fuel metabolism has been attributed in part to observed differences in epinephrine and glucagon levels during exercise between men and women. To identify the candidate mechanisms for this sex difference, we created a sex-specific multi-scale mathematical model that links cellular metabolism in organs to whole-body responses during exercise. Model simulations show that the female liver, which tends to preserve hepatic glycogen stores, is primarily responsible for the shift toward lipid metabolism. Furthermore, skeletal muscle in females uses plasma free fatty acids as its primary fuel source rather than intramyocellular lipids, whereas the opposite holds true for males.
Contact Info
Department of Applied Mathematics
University of Waterloo
Waterloo, Ontario
Canada N2L 3G1
Phone: 519-888-4567, ext. 32700
Fax: 519-746-4319
PDF files require Adobe Acrobat Reader
The University of Waterloo acknowledges that much of our work takes place on the traditional territory of the Neutral, Anishinaabeg and Haudenosaunee peoples. Our main campus is situated on the Haldimand Tract, the land granted to the Six Nations that includes six miles on each side of the Grand River. Our active work toward reconciliation takes place across our campuses through research, learning, teaching, and community building, and is co-ordinated within the Office of Indigenous Relations.