PhD comprehensive seminar | Keegan Keplinger, Modeling the switching dynamics of Aplysia bag cell neuronsExport this event to calendar

Tuesday, February 4, 2014 — 2:00 PM EST

MC 5158

Candidate

Keegan Keplinger, Applied Mathematics, University of Waterloo

Title

Modeling the switching dynamics of Aplysia bag cell neurons

Abstract

The bag cell neuron clusters of the sea slug Aplysia act as a master switch, instigating a chain of downstream peptide signaling relevant to organismal reproduction. Given a sufficient stimulus, a single bag cell neuron transitions from an excitatory cell to an oscillatory cell through a series of second-messenger mechanisms. The details of such second messengers remain unclear, but major players, such as calcium, calmodulin, protein kinase A, and protein kinase C have been indicated in the transition from excitatory dynamics to oscillatory spiking. Through collaboration with experimentalists, the objective of this research project is to build a single bag cell neuron model, complete with second-messenger dynamics, and couple it to a network of similarly constructed neurons to reproduce the dynamical switching behavior of the bag cell neuron clusters.

Location 
University of Waterloo
MC 5158

,
Canada

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