Mahla Poudineh

Assistant Professor, Electrical Engineering

Research interests: bio-sensing approaches for therapeutics and diagnostics purposes and translating biomedical devices to the clinic.

Mahla Poudineh is an Assistant Professor at the University of Waterloo, Department of Electrical Engineering. She received her Ph.D. degree in Electrical Engineering (with a minor in Biomedical Engineering) from the University of Toronto in 2016. Prior to joining UWaterloo, Mahla completed postdoctoral training at the University of Toronto, Department of Pharmaceutical Science and Stanford University, School of Medicine in 2017 and 2019, respectively. She received her B.Sc. and M.Sc. in Electrical Engineering, both from the University of Tehran, Iran in 2010 and 2012, respectively. Her research interests include developing bio-sensing approaches for therapeutics and diagnostics purposes and translating biomedical devices to the clinic.

Education

Ph.D., University of Toronto, Toronto, ON
M.Sc., University of Tehran, Tehran, Iran
B.Sc., University of Tehran, Tehran, Iran

Mahla Poudineh

Research

In Poudineh Lab, we focus on developing novel tools for effective and early disease diagnosis by detecting specific biomarkers. We aim to establish robust platforms that collect individual patient molecular and genetic profiles and combines disease diagnosis and treatment procedures into a single miniaturized device for future clinical translation. These platforms will enable personalized medicine through individual patient tracking that can be readily used next to the patient’s bedside and will potentially outperform current clinical gold standards in disease diagnostics and therapeutics. Currently, research theme in Poudineh Lab is divided into two main categories: “Multiplexed cancer biomarkers profiling” and “Personalized disease diagnostics and therapeutics.”

Research Interest

Real-time bio-sensing approaches for detection of small molecules
Microfluidic-based integrated devices for therapeutics and diagnostics purposes
Implantable micro-devices for cancer treatment
Circulating tumor cell phenotypic characterization
Stem cell profiling and characterization
Translating biomedical devices for clinical use
Silicon micro-machining for developing bio-MEMS and bio-NEMS devices

Publications

M. Poudineh*, C. L. Maikawa*, E. Yue Ma, J. Pan, D. Mamerow, Y. Hang, S. W. Baker, A. Beirami, M. Eisenstein, S. Kim, J. Vučković1, E. A. Appel, and H. T. Soh, “Continuous detection of glucose and insulin in live animals,” to be submitted to Nature Biomedical Engineering, 2019.
M. Poudineh, E. H. Sargent, S. O. Kelley, and K. Pantel, “Profiling Circulating Tumour Cells and Other Biomarkers of Invasive Cancers,” Nature Biomedical Engineering, invited review, 2018, 2, 74-82.
M. Labib, R. M. Mohamadi, M. Poudineh, S. Ahmed, I. Ivanov, C. Huang, M. Moosavi, E. H. Sargent, and S. O. Kelley, “Single Cell mRNA Cytometry via Sequence-Specific Nanoparticle Clustering and Trapping,” Nature Chemistry, 2018, 10, 489-495.
M. Poudineh*, Z. Wang*, M. Labib, M. Ahmadi, L. Zhang, J. Das, S. Ahmed, S. Angers, and S. O. Kelley, “Three Dimensional Nanostructured Architectures Enable Efficient Neural Differentiation of Mesenchymal Stem Cells via Mechanotransduction,” Nano Letters, 2018, 18, 7188-7193.
M. Poudineh, P. M. Aldridge, S. Ahmed, B. J. Green, L. Kermanshah, V. Nguyen, C. Tu, R. M. Mohamadi, R. K. Nam, A. Hansen, S. S. Sridhar, A. Finelli, N. E. Fleshner, A. M. Joshua, E. H. Sargent, and S. O. Kelley, “Tracking the Dynamics of Circulating Tumor Cell Phenotypes Using Nanoparticle-mediated Magnetic Ranking,” Nature Nanotechnology, 2017, 12, 274-282.
M. Poudineh, M. Labib, S. Ahmed, L. N. Matthew Nguyen, L. Kermanshah, R. M. Mohamadi, E. H. Sargent, and S. O. Kelley, “Profiling Functional and Biochemical Phenotypes of Circulating Tumor Cells Using a Two-Dimensional Sorting Device,” Angewantde Chemie, 2017, 56, 163-168.

Please see Mahla Poudineh's Google Scholar profile for a current list of her peer-reviewed articles.