Mass spectrometry based faster and more accurate analytical platform for biomolecules characterization
David Da Yong Chen
Department of Chemistry
University of British Columbia
Monday, December 2, 2025
11:00 a.m.
In-person: C2-361
Abstract: To identify and quantify analytes, especially those that are present in biological systems, we traditionally rely on separation methods to obtain pure compounds, then transfer them to optical, electrical or mass based detectors for characterization. These processes can be long and costly, forcing practitioners to opt for simpler and faster method while sacrificing accuracy and information contents. Simpler or newer technologies can be used to significantly speed up the analytical process. A mass spectrometer (MS) itself is a separation device base on the mass to charge ratio of particles. When coupled with liquid chromatography or capillary electrophoresis, the advantages of two-dimensional separation coupled with highly sensitive detectors are on full display. In addition, high resolution MS itself provide unprecedented separation power, and the trapping capability of many hybrid mass spectrometers can be used to isolate and characterize complex molecules, including structural isomers, within a few seconds. Some applications of MS technology on the identification and proteins, carbohydrates, and small molecules will be presented.
David Chen earned his B.Sc. from Xiamen University in 1985 and completed his Ph.D. in Chemistry at the University of Alberta in 1993 under the supervision of N. J. Dovichi. He did his postdoctoral training at the same institution from 1993 and 1994, working together with both Prof. N. J. Dovichi and J. F. Elliott.
Dr. Chen’s research focuses on analytical separation science, with a particular emphasis on advancing high-performance measurement technologies. His contributions have been recognized by several major honors, including the Royal Society of Chemistry Award in Analytical Separation Methods (2001), the UBC Charles A. McDowell Award for Excellence in Research (2002), the CSC W. A. E. McBryde Medal (2008), and the CSC Maxxam Award (2015).
Dr. Chen is widely regarded for his innovative approaches to chemical analysis and his leadership in the development of next-generation separation and detection methodologies.