Contacts

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[Global Impact] [CBC] April 30, 2018 "Working with gene therapy to treat glaucoma"

[Waterloo Stories] July 5, 2012 "Revolutionary drug delivery"

[Science Direct] August 10, 2018 "Revealing the atomistic details behind the binding of B7–1 to CD28 and CTLA-4: A comprehensive protein-protein modelling study"

[Nature] August 27, 2019 "Comprehensive in vitro characterization of PD-L1 small molecule inhibitors"

ResearchGate

[Daily Bulletin] June 1, 2018, 11 CBB Members Named Outstanding Performance Award Winners

Research interests:

Research Interests:

• Clinical trial design
• Contact lens performance
• Drug delivery
• Ocular biomaterials
• Proteins at interfaces

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University Research Chair

Office of Research - Technology Transfer & Commercialization:

• Long-lasting Eye Drop Delivery Platform for Targeted Ocular Delivery Applications

Research Interests:

• Design/discovery of potential therapeutics to target various diseases
• Understanding the structure and pharmacology of membrane proteins
• Development of in silico methods/tools for sequence, structure and functional analysis
• Inferring the structure-function evolution of proteins
• Protein engineering for biotechnology and pharmaceutical applications

[American Chemical Society] January 23, 2012 "Exploring Inhibitor Release Pathways in Histone Deacetylases Using Random Acceleration Molecular Dynamics Simulations"

[Wiley Online Library] July 27, 2013 "Ligand release mechanisms and channels in histone deacetylases"

[Royal Society of Chemistry] December 19, 2013 "A steered molecular dynamics mediated hit discovery for histone deacetylases"

[Nature Methods] May 8, 2017 "ModelFinder: fast model selection for accurate phylogenetic estimates"

[Royal Society of Chemistry] October 24, 2017 "Reverse engineering: transaminase biocatalyst development using ancestral sequence reconstruction"

Research Interests:

• Biophysics of lipids and lipid-protein interactions

• The role of structural changes and physical properties of lipid template in controlling biological processes and diseases

• Biomedical nanotechnology (lipid films, molecular mechanism of Alzheimer's disease)

• Drug development and delivery systems, antimicrobial peptides in lung disorders

• Fluorescence and atomic force microscopy

• Kelvin probe force microscopy and single molecule force spectroscopy

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[Global Impact] May 2018, studying Alzheimer's at a molecular level to find a cure

[YouTube Lecture] October 1, 2014 "Scanning probe microscopy in biomedical research"

Research Interests:

• Synthetic biology for sustainable development
• Functional probiotics for affordable and preventive health solutions
• Biomanufacturing
• Genetic tools exploring
• Bio-nanoparticles
• Bio-upcycling of mixed waste for sustainable development
• Dynamic regulation of bioprocess
• Biodegradation and Bioremediation

Google Scholar

Research interests:

• Neurodegeneration
• Huntington Disease
• Autophagy
• Apoptosis
• Fatty acylation

Google Scholar

Research interests: 

• Neurobiological embedding of adversity
• Biological characteristics that influence outcome from brain injury
• Drug development, biomarkers
• Stroke; biological characteristics that influence outcomes from brain injury

Google Scholar

Research Interests:

• Drug discovery
• Rational drug design and medicinal chemistry
• Cancer therapy
• Treatment of neurological disorders (Alzheimer's, Parkinson's)
• Drug discovery/rational design
• Synthesis and biological evaluation of novel organic molecules and peptides/peptidomimics as therapeutic agents

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[Science News] October 22, 2018 "Nekkar lab determines that depression medications can help treat Alzheimer’s disease"

​[Pharmacy News] July 29, 2015 "Waterloo pharmacist examines drug therapies for Alzheimer’s disease"

Research Interests:

• Calcium channel analysis for target drug delivery for treatment of pain, arrhythmias, angina, and potential benefits in treatment of epilepsy and cancer.

• Structure, function and pharmacology of calcium channels and sodium channels

• Structure and function and analysis of NALCN cation channel  and anti-calcium channel toxins

• The Spafford Neurobiology Research Laboratory studies voltage-gated calcium channels, molecular physiology, biophysics, cell biology, protein biochemistry, fluorescence microscopy and tissue cultures.

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[Science News] April 25, 2014 "Waterloo discovers a key regulator in the pacemakers of our brain and heart"

Research Interests:

• Medicinal chemistry/enzymology (treatment of prostate and breast cancer, diabetes)

• Nanomedicine; development of novel antibiotics

• Bionanomaterials; synthetic polymers and methodologies

• Peptide, charbohydrate, nucleoside and nucleotide chemistry

[Daily Bulletin] June 1, 2018, 11 CBB Members Named Outstanding Performance Award Winners

[Science News] February 4, 2015 "Chemists develop new method to improve the discovery of antibiotics"

Research Interests:

• Gene therapy and drug delivery systems (prostate and ovarian cancer treatment)

• Polymeric nanomaterials, biopolymers

• Novel surface active compounds (gemini surfactants)

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ResearchGate

Google Scholar

[Daily Bulletin] June 1, 2018, 11 CBB Members Named Outstanding Performance Award Winners

[CBB researcher story] July 21, 2015 "Vectors for gene therapy and improving drug solubility"