Modeling Interactions between Hydrophobic Nanosheets and Lipid Membranes
Jun Fan, City University of Hong Kong
Two-dimensional nanomaterials could cause structural disruption and cytotoxic effects to cells, which greatly challenges their promising biomedical applications including biosensing, bioimaging, and drug delivery. Here, interactions between lipid liposomes and hydrophobic nanosheets is studied utilizing coarse-grained (CG) molecular dynamics (MD) simulations. The simulations reveal a variety of interaction morphologies that depend on the size and the orientation of nanosheets.