Applied Math Mathematical Biology Seminar | Chapin Korosec, Modelling the immune system response to vaccination

MC 6460

Speaker

Chapin Korosec, York University

Title

Modelling the immune system response to vaccination 

Abstract

Following a vaccine inoculation or disease exposure an immune response develops in time, where the description of its time evolution poses an interesting problem in dynamical systems. The principal goal of theoretical immunology is to construct models capable of describing long term immunological trends from the properties and interactions of its elementary components. In this talk I will give a brief description of the human immune system and introduce a simplified version of its elementary components. I will then discuss our contributions to the field achieved through my postdoctoral work with Dr. Jane Heffernan at York University. I will focus on our mechanistic modelling work describing vaccine-generated SARS-CoV-2 immunity, applications of our work towards understanding vaccination responses in people living with HIV, and our currently unpublished discovery of increased antibody half lives following a multi-dose vaccination regimen. Finally, I will discuss our on-going work towards developing an artificial intelligence public health platform capable of predicting immune response outcomes from a multi-dose regimen.